Prevention of schizophrenia deficits via non-invasive adolescent frontal cortex stimulation in rats

被引：26

作者：

Hadar, Ravit ^{[1
,2
]}

Winter, Rebecca ^{[2
]}

Edemann-Callesen, Henriette ^{[1
,2
,3
]}

Wieske, Franziska ^{[1
]}

Habelt, Bettina ^{[1
,2
]}

Khadka, Niranjan ^{[4
]}

Felgel-Farnholz, Viktoria ^{[2
]}

Barroeta-Hlusicka, Elizabeth ^{[1
,2
]}

Reis, Janine ^{[5
]}

Tatarau, Cristian Alexandru ^{[1
]}

Funke, Klaus ^{[6
]}

Fritsch, Brita ^{[5
]}

Bernhardt, Nadine ^{[2
]}

Bikson, Marom ^{[4
]}

Nitsche, Michael A. ^{[7
,8
]}

Winter, Christine ^{[1
,2
]}

机构：

[1] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Mitte, Berlin, Germany

[2] Tech Univ Dresden, Med Fac Carl Gustav Carus, Dept Psychiat & Psychotherapy, Dresden, Germany

[3] Charite Univ Med Berlin, Int Grad Program Med Neurosci, Berlin, Germany

[4] CUNY City Coll, Dept Biomed Engn, New York, NY 10031 USA

[5] Albert Ludwigs Univ Freiburg, Univ Med Ctr, Dept Neurol, Freiburg, Germany

[6] Ruhr Univ Bochum, Dept Neurophysiol, Med Sch, Bochum, Germany

[7] TU Dortmund, Leibniz Res Ctr Working Environm & Human Factors, Dept Psychol & Neurosci, Dortmund, Germany

[8] Ruhr Univ Bochum, Univ Hosp Bergmannsheil, Dept Neurol, Bochum, Germany

来源：

MOLECULAR PSYCHIATRY | 2020年 / 25卷 / 04期

关键词：

DEEP BRAIN-STIMULATION; IMMUNE ACTIVATION; PREFRONTAL CORTEX; NEGATIVE SYMPTOMS; MODELS; NEUROGENESIS; INHIBITION; BEHAVIOR;

D O I：

10.1038/s41380-019-0356-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-invasive transcranial direct current stimulation (tDCS) during adolescence, prior to schizophrenia-relevant behavioral manifestation, prevents the development of positive symptoms and related neurobiological alterations in the maternal immune stimulation (MIS) model of schizophrenia.

引用

页码：896 / 905

页数：10

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