Sequencing-Based Measurable Residual Disease Testing in Acute Myeloid Leukemia

被引:27
作者
Yoest, Jennifer M. [1 ]
Shirai, Cara Lunn [2 ]
Duncavage, Eric J. [2 ]
机构
[1] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
[2] Washington Univ, Dept Pathol & Immunol, St Louis, MO 63110 USA
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 8卷
关键词
measurable (minimal) residual disease; acute myeloid leukemia; next generation sequencing; unique molecular identifier; error-corrected sequencing; clinical applications of NGS; AML MRD; QUANTITATIVE RT-PCR; CLONAL HEMATOPOIESIS; TANDEM DUPLICATION; INDUCTION THERAPY; RARE MUTATIONS; DIGITAL PCR; RISK; AML; DIAGNOSIS; TRANSPLANTATION;
D O I
10.3389/fcell.2020.00249
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Next generation sequencing (NGS) methods have allowed for unprecedented genomic characterization of acute myeloid leukemia (AML) over the last several years. Further advances in NGS-based methods including error correction using unique molecular identifiers (UMIs) have more recently enabled the use of NGS-based measurable residual disease (MRD) detection. This review focuses on the use of NGS-based MRD detection in AML, including basic methodologies and clinical applications.
引用
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页数:10
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