Activation of DNA damage signaling

被引：46
作者：
Ljungman, M [1 ]
机构：
[1] Univ Michigan, Sch Med, Ctr Comprehens Canc, Dept Radiat Oncol,Div Radiat & Canc Biol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2005年 / 577卷 / 1-2期
关键词：
p53; ATM; ATR; replication; transcription; DNA topology;
D O I：
10.1016/j.mrfmmm.2005.02.014
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cells respond to DNA damage by activating DNA repair and DNA damage signaling pathways. While DNA repair proteins directly interact with DNA lesions, activation of DNA damage signaling pathways may be triggered by the effect the DNA lesions have on replication, transcription or chromatin topology. This review will focus on the potential mechanisms of the activation of DNA damage-induced signal transduction pathways. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：203 / 216
页数：14
相关论文
共 118 条
[1]   BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair [J].
Abbott, DW ;
Thompson, ME ;
Robinson-Benion, C ;
Tomlinson, G ;
Jensen, RA ;
Holt, JT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18808-18812
[2]   The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways [J].
Abraham, RT .
DNA REPAIR, 2004, 3 (8-9) :919-925
[3]   Cell cycle checkpoint signaling through the ATM and ATR kinases [J].
Abraham, RT .
GENES & DEVELOPMENT, 2001, 15 (17) :2177-2196
[4]   Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation [J].
Ali, A ;
Zhang, J ;
Bao, SD ;
Liu, I ;
Otterness, D ;
Dean, NM ;
Abraham, RT ;
Wang, XF .
GENES & DEVELOPMENT, 2004, 18 (03) :249-254
[5]   ATR couples FANCD2 monoubiquitination to the DNA-damage response [J].
Andreassen, PR ;
D'Andrea, AD ;
Taniguchi, T .
GENES & DEVELOPMENT, 2004, 18 (16) :1958-1963
[6]   DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation [J].
Bakkenist, CJ ;
Kastan, MB .
NATURE, 2003, 421 (6922) :499-506
[7]   Enhanced phosphorylation of p53 by ATN in response to DNA damage [J].
Banin, S ;
Moyal, L ;
Shieh, SY ;
Taya, Y ;
Anderson, CW ;
Chessa, L ;
Smorodinsky, NI ;
Prives, C ;
Reiss, Y ;
Shiloh, Y ;
Ziv, Y .
SCIENCE, 1998, 281 (5383) :1674-1677
[8]   ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses [J].
Bao, SD ;
Tibbetts, RS ;
Brumbaugh, KM ;
Fang, YN ;
Richardson, DA ;
Ali, A ;
Chen, SM ;
Abraham, RT ;
Wang, XF .
NATURE, 2001, 411 (6840) :969-974
[9]   ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation [J].
Barr, SM ;
Leung, CG ;
Chang, EE ;
Cimprich, KA .
CURRENT BIOLOGY, 2003, 13 (12) :1047-1051
[10]   Checking on DNA damage in S phase [J].
Bartek, J ;
Lukas, C ;
Lukas, J .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (10) :792-804
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