Effects of YC-1 targeting hypoxia-inducible factor 1 alpha in oesophageal squamous carcinoma cell line Eca109 cells

被引：16

作者：

Feng, Yadong ^{[1
]}

Zhu, Hong ^{[1
]}

Ling, Tingsheng ^{[1
]}

Hao, Bo ^{[1
]}

Zhang, Guoxin ^{[1
]}

Shi, Ruihua ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanjing 210029, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2011年 / 35卷 / 05期

基金：

中国国家自然科学基金;

关键词：

apoptosis; ESCC; hypoxia; proliferation; YC-1; ENDOTHELIAL GROWTH-FACTOR; EXPRESSION; HIF-1-ALPHA; HIF-1; SUPPRESSION; ACTIVATION; GENE; OVEREXPRESSION; METASTASIS; INHIBITION;

D O I：

10.1042/CBI20090419

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HIF-1 alpha: (hypoxia-inducible factor 1 alpha) is believed to promote oesophageal squamous tumour growth. Thus, an HIF-1 alpha inhibitor is viewed as a therapeutic target in treating oesophageal cancer. Recently, YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] has been widely used as a potential HIF-1 alpha inhibitor and is being developed as a novel anticancer drug. However, little is known about the effects of YC-1 in human oesophageal cancer. In the present study, we aimed to investigate these effects in an esophageal squamous cancer cell line; i.e. Eca109 cells. We found that YC-1 abolished the hypoxia-induced up-regulation of HIF-1 alpha. YC-1 arrested cell growth and inhibited cell migration activities in Eca109 cells. These results suggest that YC-1 may be a chemotherapy candidate against oesophageal squamous cancers.

引用

页码：491 / 497

页数：7

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