Cell Injection Millirobot Development and Evaluation in Microfluidic Chip

被引：13

作者：

Feng, Lin ^{[1
,2
]}

Zhou, Qiang ^{[1
]}

Song, Bin ^{[1
]}

Feng, Yanmin ^{[1
,2
]}

Cai, Jun ^{[1
]}

Jiang, Yonggang ^{[1
]}

Zhang, Deyuan ^{[1
,2
]}

机构：

[1] Beihang Univ, Sch Mech Engn & Automat, Beijing 100191, Peoples R China

[2] Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing 100083, Peoples R China

来源：

MICROMACHINES | 2018年 / 9卷 / 11期

关键词：

millirobot; injection; cell nucleus; magnetic control; cell surgery; DRIVEN; MICROROBOT;

D O I：

10.3390/mi9110590

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We propose an innovative design of millirobot, which can achieve donor cell suction, delivery, and injection in a mammalian oocyte on a microfluidic chip. The millirobot body contains a hollow space that produces suction and ejection forces for the injection of cell nuclei using a nozzle at the tip of the robot. Specifically, a controller changes the hollow volume by balancing the magnetic and elastic forces of a membrane along with the motion of stages in the XY plane. A glass capillary attached to the tip of the robot contains a nozzle that is able to absorb and inject cell nuclei. The millirobot provides three degrees of freedom and generates micronewton forces. We demonstrate the effectiveness of the proposed millirobot through an experiment of the absorption and ejection of 20-mu m particles from the nozzle using magnetic control in a microfluidic chip.

引用

页数：11

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