Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prunifera against Triton WR-1339 and hyperlipidemic diet in mice

被引：13

作者：

Filho, A. C. V. A. ^{[1
]}

Rodrigues, P. A. S. ^{[1
]}

Benjamin, S. R. ^{[1
]}

Paim, R. T. T. ^{[1
]}

Holanda, M. O. ^{[1
]}

Silva, J. Y. G. ^{[1
]}

Milo, T. S. ^{[1
]}

Vieira, I. G. P. ^{[1
]}

Queiroz, M. G. R. ^{[2
]}

Guedes, M. I. F. ^{[1
]}

机构：

[1] Univ Estadual Ceara, Biotechnol & Mol Biol Lab, BR-60740903 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Odontol, Fortaleza, Ceara, Brazil

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2017年 / 56卷

关键词：

Camauba wax; Cinnamic acid esters; Dyslipidemia; Triton WR-1339; Hyperlipidemic diet; ANTIOXIDANT ACTIVITY; PHYLLANTHUS-NIRURI; CARNAUBA WAX; ACIDS; HYPERCHOLESTEROLEMIA; ORYZANOL; HAMSTERS; EXTRACT; DISEASE; LIPASE;

D O I：

10.1016/j.etap.2017.09.015

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Carnauba wax is extracted from the leaves of the Copernicia prunifera and contains approximately 80% of esters in its composition. The purpose of the present study was evaluate the hypolipidemic effect of p-methoxycinnamic diesters (PCO-C) extracted from Copernicia pruntfera in a model of acute and chronic dyslipidemia in mice. The levels of total cholesterol and triglycerides were significantly reduced plasma levels in PCO-C at the dose of 100 mg/kg in a model of acute and chronic dyslipidemia. Histological studies showed that PCO-C has no hepatotoxic effect and reduces hepatic steatosis in animals that consumed hyperlipidemic ration. Thus, it was concluded that PCO-C isolated from Copernicia Prunifera was effective in reducing total cholesterol and triglyceride levels in both dyslipidemia induction models. The finding indicates that PCO-C might be beneficial in treatment of hyperlipidemia and atherosclerosis.

引用

页码：198 / 203

页数：6

共 4 条

[1] Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats
Rony, K. A.
Ajith, T. A.
Nima, N.
Janardhanan, K. K.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2014, 37 (02) : 482 - 492
[2] Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice
Chen, Jingjing
Li, Xiangrong
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION, 2007, 16 : 290 - 294
[3] Therapeutical effect of olive oil aggregate to 4-methoxycinnamic acid diester obtained from carnauba (Copernicia prunifera) wax (PCO-C) on dyslipidemia, hyperglycemia, and oxidative stress
Silva, Iramaia Bruno
da Silva, Antonio Wlisses
Reboucas, Emanuela Lima
Coutinho, Marnielle Rodrigues
Canabrava, Natalia do Vale
da Silva, Jose Ytalo Gomes
Guedes, Maria Izabel Florindo
FOOD BIOSCIENCE, 2021, 44
[4] Effect and evaluation of antihyperlipidemic activity guided isolated fraction from total methanol extract of Salvadora oleoides (Decne.) in Triton WR-1339 Induced hyperlipidemic rats
Kumar, Deepak
Parcha, Versha
Maithani, Alok
Dhulia, Lshan
PHARMACOGNOSY MAGAZINE, 2012, 8 (32) : 314 - 318

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