Metabolic Derangements Seen in Chronic Kidney Disease and End-Stage Renal Disease Patients

The National Health and Nutrition Examination Survey (NHANES) shows increasing trends in the prevalence of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in the US population. There is an inverse relationship between a declining glomerular filtration rate and mortality and morbidity. A wide spectrum of complex metabolic derangements contributes to a large extent for this increased mortality and morbidity. An overview of some of these metabolic derangements like uremic dyslipidemia, uremic inflammation, and endocrine abnormalities affecting thyroid and sexual functioning of CKD patients - is provided. Understanding some of these metabolic derangements may help develop new and affective strategies to help reduce mortality and morbidity among CKD patients. Copyright (C) 2011 S. Karger AG, Basel