Advances in multifunctional glycosylated nanomaterials: preparation and applications in glycoscience

被引：34
作者：
Adak, Avijit K. [1 ]
Li, Ben-Yuan [1 ]
Lin, Chun-Cheng [1 ]
机构：
[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan
来源：
CARBOHYDRATE RESEARCH | 2015年 / 405卷
关键词：
Glyconanoparticles; Multivalent interaction; Biolabels; Cellular imaging; Target-specific delivery; Glycosyltransferase activity; ENCAPSULATED GOLD NANOPARTICLES; MAGNETIC GLYCO-NANOPARTICLES; DRUG-DELIVERY SYSTEMS; QUANTUM DOTS; CARBOHYDRATE INTERACTIONS; QUANTITATIVE-ANALYSIS; CANCER VACCINES; CELLULAR UPTAKE; GLYCONANOPARTICLES; LECTIN;
D O I：
10.1016/j.carres.2014.07.026
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Applications of glycosylated nanomaterials have gained considerable attention in recent years due to their unique structural properties and compatibility in biological systems. In this review, glyco-nanoparticles (glyco-NPs) are defined as compounds that contain a nano-sized metallic core, are composed of noble metals, magnetic elements, or binary inorganic nanoparticles, and that exhibit carbohydrate ligands on the surface in three dimensional polyvalent displays similar to the glycocalyx structures on cell membranes. Nanomaterials decorated with suitable biological recognition ligands have yielded novel hybrid nanobiomaterials with synergistic functions, especially in biomedical applications. This review focuses on strategies for building various types of glyco-NPs and highlights their potential in targeted drug delivery and molecular imaging as well as their uses in bioassays and biosensors. The most recent examples of glyco-NPs as vaccine candidates and probes for assaying enzymes with bond-forming activities are also discussed. (C) 2014 Elsevier Ltd. All rights reserved.
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页码：2 / 12
页数：11
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