Advances in multifunctional glycosylated nanomaterials: preparation and applications in glycoscience

被引：34

作者：

Adak, Avijit K. ^{[1
]}

Li, Ben-Yuan ^{[1
]}

Lin, Chun-Cheng ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

CARBOHYDRATE RESEARCH | 2015年 / 405卷

关键词：

Glyconanoparticles; Multivalent interaction; Biolabels; Cellular imaging; Target-specific delivery; Glycosyltransferase activity; ENCAPSULATED GOLD NANOPARTICLES; MAGNETIC GLYCO-NANOPARTICLES; DRUG-DELIVERY SYSTEMS; QUANTUM DOTS; CARBOHYDRATE INTERACTIONS; QUANTITATIVE-ANALYSIS; CANCER VACCINES; CELLULAR UPTAKE; GLYCONANOPARTICLES; LECTIN;

D O I：

10.1016/j.carres.2014.07.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Applications of glycosylated nanomaterials have gained considerable attention in recent years due to their unique structural properties and compatibility in biological systems. In this review, glyco-nanoparticles (glyco-NPs) are defined as compounds that contain a nano-sized metallic core, are composed of noble metals, magnetic elements, or binary inorganic nanoparticles, and that exhibit carbohydrate ligands on the surface in three dimensional polyvalent displays similar to the glycocalyx structures on cell membranes. Nanomaterials decorated with suitable biological recognition ligands have yielded novel hybrid nanobiomaterials with synergistic functions, especially in biomedical applications. This review focuses on strategies for building various types of glyco-NPs and highlights their potential in targeted drug delivery and molecular imaging as well as their uses in bioassays and biosensors. The most recent examples of glyco-NPs as vaccine candidates and probes for assaying enzymes with bond-forming activities are also discussed. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：2 / 12

页数：11

共 94 条

[1] Cellular Uptake of Gold Nanoparticles Bearing HIV gp120 Oligomannosides [J].

Arnaiz, Blanca ;

Martinez-Avila, Olga ;

Falcon-Perez, Juan M. ;

Penades, Soledad .

BIOCONJUGATE CHEMISTRY, 2012, 23 (04) :814-825

[2] Carbohydrate vaccines: developing sweet solutions to sticky situations? [J].

Astronomo, Rena D. ;

Burton, Dennis R. .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (04) :308-324

[3] β-Cyclodextrin-Bearing Gold Glyconanoparticles for the Development of Site Specific Drug Delivery Systems [J].

Aykac, Ahmet ;

Martos-Maldonado, Manuel C. ;

Casas-Solvas, Juan M. ;

Quesada-Soriano, Indalecio ;

Garcia-Maroto, Federico ;

Garcia-Fuentes, Luis ;

Vargas-Berenguel, Antonio .

LANGMUIR, 2014, 30 (01) :234-242

[4] Sugar-quantum dot conjugates for a selective and sensitive detection of lectins [J].

Babu, Ponnusamy ;

Sinha, Sharmistha ;

Surolia, Avadhesha .

BIOCONJUGATE CHEMISTRY, 2007, 18 (01) :146-151

[5] Magnetic Porous Sugar-Functionalized PEG Microgels for Efficient Isolation and Removal of Bacteria from Solution [J].

Behra, Muriel ;

Azzouz, Nahid ;

Schmidt, Stephan ;

Volodkin, Dmitry V. ;

Mosca, Simone ;

Chanana, Munish ;

Seeberger, Peter H. ;

Hartmann, Laura .

BIOMACROMOLECULES, 2013, 14 (06) :1927-1935

[6] Design and Synthesis of Multifunctional Gold Nanoparticles Bearing Tumor-Associated Glycopeptide Antigens as Potential Cancer Vaccines [J].

Brinas, Raymond P. ;

Sundgren, Andreas ;

Sahoo, Padmini ;

Morey, Susan ;

Rittenhouse-Olson, Kate ;

Wilding, Greg E. ;

Deng, Wei ;

Barchi, Joseph J., Jr. .

BIOCONJUGATE CHEMISTRY, 2012, 23 (08) :1513-1523

[7] SYNTHESIS OF THIOL-DERIVATIZED GOLD NANOPARTICLES IN A 2-PHASE LIQUID-LIQUID SYSTEM [J].

BRUST, M ;

WALKER, M ;

BETHELL, D ;

SCHIFFRIN, DJ ;

WHYMAN, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (07) :801-802

[8] Multivalent glycoconjugate syntheses and applications using aromatic scaffolds [J].

Chabre, Yoann M. ;

Roy, Rene .

CHEMICAL SOCIETY REVIEWS, 2013, 42 (11) :4657-4708

[9] A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells [J].

Chen, Chien-Tien ;

Munot, Yogesh S. ;

Salunke, Santosh B. ;

Wang, Yi-Ching ;

Lin, Ruo-Kai ;

Lin, Chun-Cheng ;

Chen, Chia-Chun ;

Liu, Y-Hsin .

ADVANCED FUNCTIONAL MATERIALS, 2008, 18 (04) :527-540

[10]

Chen YF, 2003, NANO LETT, V3, P581, DOI [10.1021/nl034086g, 10.1021/n1034086g]

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