Fabrication and characterization of hardystonite-chitosan biocomposite scaffolds

被引：28

作者：

Caballero, Silvia Stella Ramirez ^{[1
,2
]}

Elsayed, Hamada ^{[3
,4
]}

Tadier, Solene ^{[1
]}

Montembault, Alexandra ^{[2
]}

Maire, Eric ^{[1
]}

David, Laurent ^{[2
]}

Delair, Thierry ^{[2
]}

Colombo, Paolo ^{[3
,5
]}

Gremillard, Laurent ^{[1
]}

机构：

[1] Univ Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, CNRS,MATEIS,UMR5510, F-69621 Villeurbanne, France

[2] Univ Claude Bernard Lyon 1, Univ Lyon, CNRS, Ingn Mat Polymeres,IMP Lyon1,UMR 5223, F-69622 Villeurbanne, France

[3] Univ Padua, Dipartimento Ingn Ind, Via Marzolo 9, I-35131 Padua, Italy

[4] Natl Res Ctr, Dept Ceram, El Bohous St, Cairo 12622, Egypt

[5] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16801 USA

来源：

CERAMICS INTERNATIONAL | 2019年 / 45卷 / 07期

关键词：

Direct ink writing; Physical hydrogels; Polymer impregnation; Bone substitutes; Ceramic-polymer composites; Fracture; MECHANICAL-PROPERTIES; PHOSPHATE SCAFFOLDS; POLYMER; BIOCOMPATIBILITY; CERAMICS; STRENGTH; COATINGS; CHITIN; POLYCAPROLACTONE; HYDROXYAPATITE;

D O I：

10.1016/j.ceramint.2019.01.206

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

2 Hardystonite scaffolds produced by ceramization of 3-D printed preceramic filled polymer were impregnated with chitosan solutions, later neutralized into physical hydrogels. Hardystonite bioceramic and chitosan physical hydrogel were chosen for their interesting biological properties as potential bone substitutes. Five impregnation protocols, differing in impregnation vacuum, chitosan concentration, chitosan to hardystonite mass ratio and base used for chitosan gelation were studied. The composition, micropore structure and surface morphology of impregnated scaffolds were determined. Impregnated hardystonite scaffolds were tested to find out the effect of impregnation protocols on elastic and dissipative mechanical properties of the composites. The capacity for energy dissipation and for load bearing increased as chitosan content increased in the composites. Thus, 3-D architectured biocomposites with enhanced mechanical properties can be manufactured following the method shown in this article.

引用

页码：8804 / 8814

页数：11

共 41 条

[1]

Amini Ami R., 2012, Critical Reviews in Biomedical Engineering, V40, P363

[2] Chitin and chitosan in selected biomedical applications [J].