Moringa oleifera Leaf Ethanolic Extract Subsidized by Low Doses of Gamma Irradiation Modulates the Thioacetamide Induced Fibrotic Signs in Liver of Albino Rats

被引：0

作者：

Moustafa, Enas Mahmoud ^{[1
]}

Abdel-Rafei, Mohamed Khairy ^{[1
]}

Thabet, Noura Magdy ^{[1
]}

Hasan, Hesham Farouk ^{[1
]}

机构：

[1] NCRRT, Radiat Biol Dept, Atom Energy Author, Cairo, Egypt

来源：

PAKISTAN JOURNAL OF ZOOLOGY | 2015年 / 47卷 / 03期

关键词：

Liver fibrosis; Moringa oleifera; gamma-irradiation; thioacetamide; LIPID-PEROXIDATION; RAY IRRADIATION; CORD BLOOD; ANTIOXIDANT; DAMAGE; MICE; GLUTATHIONE; EXPRESSION; FIBROSIS; INJURY;

D O I：

暂无

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

The objective was to evaluate the role of ethanolic extract of Moringa oleifera leaf (MOE) administered orally followed by low doses of gamma-irradiation (LDR) on thioacetamide (TAA) induced liver fibrosis in female albino rats. LDR treatment was performed by whole body gamma-irradiation of animals with 0.25Gy applied on the 1st and 15th day. Biochemical analysis in the serum of TAA-treated rats revealed a significant increase in the levels of tumor necrosis factor (TNF-alpha) and transforming growth factor (TGF-beta), as well as, the activities of aspartate amino transferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GOT). In addition, a significant elevation of malondialdehyde (MDA), hydroxyproline (HYP) and nitric oxide (NO) levels associated to a significant decrease of reduced glutathione (GSH) content was recorded in the liver of TAA-treated rats. Histopathological examination of liver sections depicted fibroblasts proliferation surrounding cytomegalic hepatocytes. A significant amelioration of liver damage was recorded in rats receiving MOE and/or LDR treatment. It could be concluded that exposure to LDR intensifies the effectiveness of MOB against liver fibrosis induced by TAA in rats.

引用

页码：793 / 802

页数：10