Diels-Alder Cycloaddition Reactions in Sustainable Media

被引：20
作者：
Soares, Maria I. L. [1 ,2 ]
Cardoso, Ana L. [1 ,2 ]
Melo, Teresa M. V. D. Pinho E. [1 ,2 ]
机构：
[1] Univ Coimbra, Coimbra Chem Ctr, Inst Mol Sci, P-3004535 Coimbra, Portugal
[2] Univ Coimbra, Dept Chem, P-3004535 Coimbra, Portugal
来源：
MOLECULES | 2022年 / 27卷 / 04期
关键词：
Diels-Alder reaction; green solvent; bio-based solvent; deep eutectic solvents; water; DEEP EUTECTIC SOLVENTS; CATALYST-FREE SYNTHESIS; ANNULATED THIOPYRANOCOUMARIN DERIVATIVES; SUPERCRITICAL CARBON-DIOXIDE; BIOMASS-DERIVED SOLVENTS; DOMINO-KNOEVENAGEL; ORGANIC-SYNTHESIS; ON-WATER; ONE-POT; DIASTEREOSELECTIVE SYNTHESIS;
D O I：
10.3390/molecules27041304
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diels-Alder cycloaddition reaction is one of the most powerful strategies for the construction of six-membered carbocyclic and heterocyclic systems, in most cases with high regio- and stereoselectivity. In this review, an insight into the most relevant advances on sustainable Diels-Alder reactions since 2010 is provided. Various environmentally benign solvent systems are discussed, namely bio-based derived solvents (such as glycerol and gluconic acid), polyethylene glycol, deep eutectic solvents, supercritical carbon dioxide, water and water-based aqueous systems. Issues such as method's scope, efficiency, selectivity and reaction mechanism, as well as sustainability, advantages and limitations of these reaction media, are addressed.
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页数：46
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