Targeting endoplasmic reticulum stress using natural products in neurological disorders

被引：13
|
作者：
Jangra, Ashok [1 ]
Verma, Mehak [1 ]
Kumar, Deepak [1 ]
Chandrika [1 ]
Rachamalla, Mahesh [2 ]
Dey, Abhijit [3 ]
Dua, Kamal [4 ]
Jha, Saurabh Kumar [5 ,6 ,7 ]
Ojha, Shreesh [8 ]
Alexiou, Athanasios [9 ]
Kumar, Dinesh [1 ]
Jha, Niraj Kumar [5 ,6 ,7 ]
机构：
[1] Cent Univ Haryana, Dept Pharmaceut Sci, Mahendergarh 123031, Haryana, India
[2] Univ Saskatchewan, Dept Biol, 112 Sci Pl, Saskatoon, SK S7N 5E2, Canada
[3] Presidency Univ, Dept Life Sci, 86-1 Coll St, Kolkata 700073, W Bengal, India
[4] Univ Technol Sydney, Australian Res Ctr Complementary & Integrat Med, Fac Hlth, Discipline Pharm,Grad Sch Hlth, Ultimo, NSW 2007, Australia
[5] Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Plot 32-34 Knowledge Pk 3, Greater Noida 201310, Uttar Pradesh, India
[6] Chandigarh Univ, Dept Biotechnol Engn & Food Technol, Mohali 140413, India
[7] Uttaranchal Univ, Sch Appl & Life Sci SALS, Dept Biotechnol, Dehra Dun 248007, Uttarakhand, India
[8] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Abu Dhabi, U Arab Emirates
[9] Novel Global Community Educ Fdn, Dept Sci & Engn, Hebersham, NSW 2770, Australia
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2022年 / 141卷
关键词：
Keywords; Endoplasmic reticulum stress; Natural products; Neurological disorders; Neurodegenerative diseases; Neuroprotection; Neuroprotective agents; Alzheimer ?s disease; Parkinson ?s disease; ISCHEMIA-REPERFUSION INJURY; UNFOLDED PROTEIN RESPONSE; MEDIATED INFLAMMATORY PATHWAYS; INDUCED COGNITIVE IMPAIRMENTS; INDUCED BEHAVIORAL DEFICITS; INDUCED NEURONAL APOPTOSIS; GASTRODIA-ELATA BLUME; BLOOD-BRAIN-BARRIER; SPINAL-CORD-INJURY; ER STRESS;
D O I：
10.1016/j.neubiorev.2022.104818
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publica-tions. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed.
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页数：23
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