Relationship between an indel mutation within the SIRT4 gene and growth traits in Chinese cattle

被引：10
作者：
Zhang, Qingfeng [1 ,2 ]
Jin, Yunyun [3 ]
Jiang, Fugui [1 ,2 ]
Cheng, Haijian [1 ,2 ]
Wang, Yafang [1 ,4 ]
Lan, Xianyong [3 ]
Song, Enliang [1 ,2 ]
机构：
[1] Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250100, Shandong, Peoples R China
[2] Shandong Key Lab Anim Dis control & Breeding, Jinan, Shandong, Peoples R China
[3] Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling, Shaanxi, Peoples R China
[4] Shandong Normal Univ, Coll Life Sci, Jinan, Shandong, Peoples R China
来源：
ANIMAL BIOTECHNOLOGY | 2019年 / 30卷 / 04期
关键词：
Cattle; SIRT4; insertion/deletion (indel); growth traits; association; MESSENGER-RNA EXPRESSION; COPY NUMBER VARIATIONS; PHENOTYPIC TRAITS; PROMOTER ACTIVITY; LITTER SIZE; BODY-SIZE; ARMS-PCR; POLYMORPHISMS; INSERTION/DELETION; SIRTUINS;
D O I：
10.1080/10495398.2018.1520716
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Growth traits are mainly determined by genetic factors. SIRT4, a class II sirtuin, predominantly acts as an ADP-ribosyltransferase and inhibits fatty acid oxidation. In this study, a total of 1005 cattle belonging to five indigenous Chinese breeds were used to evaluate the relationship between the potential insertions/deletions (indels) within the SIRT4 gene and growth traits. The results revealed that only one intronic variation was present, which showed Hardy-Weinberg equilibrium (p > 0.05) in all the populations. The relationship analyses indicated that this indel was significantly associated with growth traits (p < 0.05), implying that SIRT4 significantly affects the growth traits. Therefore, the deletion mutation within the SIRT4 gene could be considered as a molecular marker to screen for growth traits in the cattle industry.
引用
收藏
页码：352 / 357
页数：6
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