Epidemiology and neonatal pain management of heelsticks in intensive care units: EPIPPAIN 2, a prospective observational study

被引:62
作者
Courtois, Emilie [1 ,2 ]
Droutman, Stephanie [3 ]
Magny, Jean-Francois [4 ]
Merchaoui, Zied [5 ]
Durrmeyer, Xavier [2 ,6 ]
Roussel, Camille [7 ]
Biran, Valerie [8 ]
Eleni, Sergio [9 ]
Vottier, Gaelle [10 ]
Renolleau, Sylvain [11 ]
Desfrere, Luc [12 ]
Castela, Florence [13 ]
Boimond, Nicolas [14 ]
Mellah, Djamel [15 ]
Bolot, Pascal [16 ]
Coursol, Anne [17 ]
Brault, Dominique [18 ]
Chappuy, Helene [1 ]
Cimerman, Patricia [19 ]
Anand, Kanwaljeet J. S. [20 ]
Carbajal, Ricardo [1 ,2 ,21 ]
机构
[1] Hop Armand Trousseau, Emergency Dept, Paris, France
[2] Paris Descartes Univ, DHU Risks Pregnancy, Ctr Epidemiol & Stat, Sorbonne Paris Cite,Inserm UMR Obstetr Perinatal, Paris, France
[3] Hop Andre Gregoire, NICU, Montreuil, France
[4] Inst Puericulture & Perinatal, NICU, Paris, France
[5] Hop Bicetre, PICU, Le Kremlin Bicetre, France
[6] Ctr Hosp Intercommunal Creteil, NICU, Creteil, France
[7] Hop Antoine Beclere, NICU, Clamart, France
[8] Hop Robert Debre, NICU, Paris, France
[9] Hop Louise Michel, NICU, Evry, France
[10] Hop Cochin Port Royal, NICU, Paris, France
[11] Hop Armand Trousseau, PICU, Paris, France
[12] Hop Louis Mourier, NICU, Colombes, France
[13] Intercommunal Poissy, NICU, Poissy, France
[14] Hop Necker Enfants Malad, PICU, Paris, France
[15] Ctr Hosp Meaux, NICU, Meaux, France
[16] Ctr Hosp Delafontaine, NICU, St Denis, France
[17] Ctr Hosp Rene Dubos, NICU, Cergy Pontoise, France
[18] Ctr Hosp Victor Dupouy, NICU, Argenteuil, France
[19] Hop Armand Trousseau, Ctr Natl Ressources Lutte Douleur, Paris, France
[20] Univ Tennessee, Ctr Hlth Sci, Crit Care Med Div, Dept Pediat, Memphis, TN 38163 USA
[21] UPMC, Paris, France
关键词
Epidemiology; Heel lance; Heelstick; Neonatal intensive care unit; Neonate; Nursing care; Pain management; Procedural pain; HEEL-STICK PROCEDURES; NONNUTRITIVE SUCKING; PRETERM INFANTS; FACILITATED TUCKING; INVASIVE PROCEDURES; PROCEDURAL PAIN; ORAL SUCROSE; ANALGESIA; BRAIN; TERM;
D O I
10.1016/j.ijnurstu.2016.03.014
中图分类号
R47 [护理学];
学科分类号
1011 ;
摘要
Background: Heelstick is the most frequently performed skin-breaking procedure in the neonatal intensive care units (NICUs). There are no large multicenter studies describing the frequency and analgesic approaches used for heelsticks performed in NICUs. Objectives: To describe the frequency of heelsticks and their analgesic management in newborns in the NICU. To determine the factors associated with the lack of specific preprocedural analgesia for this procedure. Design: EPIPPAIN 2 (Epidemiology of Procedural PAin In Neonates) is a descriptive prospective epidemiologic study. Setting: All 16 NICUs in the Paris region in France. Participants: All newborns in the NICU with a maximum corrected age of 44 weeks +6 days of gestation on admission who had at least one heelstick during the study period were eligible for the study. The study included 562 newborns. Methods: Data on all heelsticks and their corresponding analgesic therapies were prospectively collected. The inclusion period lasted six weeks, from June 2, 2011 to July 12, 2011. Newborns were followed from their admission to the 14th day of their NICU stay or discharge, whichever occurred first. Results: The mean (SD) gestational age was 33.3 (4.4) weeks and duration of participation was 7.5 (4.4) days. The mean (SD; range) of heelsticks per neonate was 16.0 (14.4; 1-86) during the study period. Of the 8995 heelsticks studied, 2379 (26.4%) were performed with continuous analgesia, 5236 (58.2%)with specific preprocedural analgesia. Overall, 6764 (75.2%) heelsticks were performed with analgesia (continuous and/or specific). In a multivariate model, the increased lack of preprocedural analgesia was associated with female sex, term birth, high illness severity, tracheal or noninvasive ventilation, parental absence and use of continuous sedation/analgesia Conclusions: Heelstick was very frequently performed in NICUs. Although, most heelsticks were performed with analgesia, this was not systematic. The high frequency of this procedure and the known adverse effects of repetitive pain in neonates should encourage the search of safe and effective strategies to reduce their number. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:79 / 88
页数:10
相关论文
共 49 条
[1]  
AFSSAPS, 2009, GUID FRENCH AG FOOD
[2]   Analgesia and local anesthesia during invasive procedures in the neonate [J].
Anand, KJS ;
Johnston, CC ;
Oberlander, TF ;
Taddio, A ;
Lehr, VT ;
Walco, GA .
CLINICAL THERAPEUTICS, 2005, 27 (06) :844-876
[3]  
[Anonymous], 2010, GUID DRAW BLOOD BEST
[4]   'Facilitated tucking by parents' in pain management of preterm infants -: a randomized crossover trial [J].
Axelin, Anna ;
Salantera, Sanna ;
Lehtonen, Liisa .
EARLY HUMAN DEVELOPMENT, 2006, 82 (04) :241-247
[5]   EXPOSURE TO INVASIVE PROCEDURES IN NEONATAL INTENSIVE-CARE UNIT ADMISSIONS [J].
BARKER, DP ;
RUTTER, N .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 1995, 72 (01) :F47-F48
[6]   Analgesia induced by localized injection of opiate peptides into the brain of infant rats [J].
Barr, G. A. ;
Wang, S. .
EUROPEAN JOURNAL OF PAIN, 2013, 17 (05) :676-691
[7]   Vulnerability of the developing brain - Neuronal mechanisms [J].
Bhutta, AT ;
Anand, KJS .
CLINICS IN PERINATOLOGY, 2002, 29 (03) :357-+
[8]   Morphine does not provide adequate analgesia for acute procedural pain among preterm neonates [J].
Carbajal, R ;
Lenclen, R ;
Jugie, M ;
Paupe, A ;
Barton, BA ;
Anand, KJS .
PEDIATRICS, 2005, 115 (06) :1494-1500
[9]   Epidemiology and treatment of painful procedures in neonates in intensive care units [J].
Carbajal, Ricardo ;
Rousset, Andre ;
Danan, Claude ;
Coquery, Sarah ;
Nolent, Paul ;
Ducrocq, Sarah ;
Saizou, Carole ;
Lapillonne, Alexandre ;
Granier, Michele ;
Durand, Philippe ;
Lenclen, Richard ;
Coursol, Anne ;
Hubert, Philippe ;
de Saint Blanquat, Laure ;
Boelle, Pierre-Yves ;
Annequin, Daniel ;
Cimerman, Patricia ;
Anand, K. J. S. ;
Breart, Gerard .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (01) :60-70
[10]   Breastfeeding or oral sucrose solution in term neonates receiving heel lance: A randomized, controlled trial [J].
Codipietro, Luigi ;
Ceccarelli, Manuela ;
Ponzone, Alberto .
PEDIATRICS, 2008, 122 (03) :E716-E721