Role of Body-Fluid Biomarkers in Alzheimer's Disease Diagnosis

被引：18

作者：

Nguyen, Thuy Trang ^{[1
]}

Ta, Qui Thanh Hoai ^{[2
]}

Nguyen, Thi Kim Oanh ^{[3
]}

Nguyen, Thi Thuy Dung ^{[4
]}

Vo, Van Giau ^{[5
,6
]}

机构：

[1] Ho Chi Minh City Univ Technol HUTECH, Fac Pharm, Ho Chi Minh City 700000, Vietnam

[2] Duy Tan Univ, Inst Res & Dev, Danang 550000, Vietnam

[3] Ho Chi Minh City Univ Food Ind, Fac Food Sci & Technol, Ho Chi Minh City 700000, Vietnam

[4] Nguyen Tat Thanh Univ, Fac Environm & Food Engn, Ho Chi Minh City 70000, Vietnam

[5] Gachon Univ, Grad Sch Environm, Dept Ind & Environm Engn, 1342 Sungnam Daero, Seongnam Si 461701, Gyeonggi Do, South Korea

[6] Gachon Univ, Dept BionanoTechnol, 1342 Sungnam Daero, Seongnam Si 461701, Gyeonggi Do, South Korea

来源：

DIAGNOSTICS | 2020年 / 10卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Alzheimer's disease; biomarkers; diagnostics; A beta; CSF; tau; MILD COGNITIVE IMPAIRMENT; PLASMA AMYLOID-BETA; HUMAN CEREBROSPINAL-FLUID; CSF BIOMARKERS; PHOSPHORYLATED-TAU; SYNAPTIC DEGENERATION; OCULAR BIOMARKERS; PRECURSOR PROTEIN; PATHOLOGY; DECLINE;

D O I：

10.3390/diagnostics10050326

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alzheimer's disease (AD) is a complex neurodegenerative disease that requires extremely specific biomarkers for its diagnosis. For current diagnostics capable of identifying AD, the development and validation of early stage biomarkers is a top research priority. Body-fluid biomarkers might closely reflect synaptic dysfunction in the brain and, thereby, could contribute to improving diagnostic accuracy and monitoring disease progression, and serve as markers for assessing the response to disease-modifying therapies at early onset. Here, we highlight current advances in the research on the capabilities of body-fluid biomarkers and their role in AD pathology. Then, we describe and discuss current applications of the potential biomarkers in clinical diagnostics in AD.

引用

页数：17

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