Cognitive processes in disorders of consciousness as revealed by EEG time-frequency analyses

被引：64

作者：

Fellinger, R. ^{[1
,2
]}

Klimesch, W. ^{[1
,2
]}

Schnakers, C. ^{[3
]}

Perrin, F. ^{[4
]}

Freunberger, R. ^{[1
,2
,5
]}

Gruber, W. ^{[1
,2
]}

Laureys, S. ^{[3
]}

Schabus, M. ^{[1
,2
]}

机构：

[1] Salzburg Univ, Dept Psychol, Lab Sleep & Consciousness Res, A-5020 Salzburg, Austria

[2] Salzburg Univ, Div Physiol Psychol, A-5020 Salzburg, Austria

[3] Univ Liege, Cyclotron Res Ctr, B-4000 Liege, Belgium

[4] Univ Lyon 1, CNRS, Neurosci & Syst Sensoriels Unite Mixte Rech 5020, F-69007 Lyon, France

[5] Max Planck Inst Human Dev, Ctr Lifespan Psychol, D-14195 Berlin, Germany

来源：

CLINICAL NEUROPHYSIOLOGY | 2011年 / 122卷 / 11期

关键词：

Frontal theta; Vegetative state; Minimally conscious state; Awareness; FRONTAL MIDLINE THETA; EVENT-RELATED POTENTIALS; WORKING-MEMORY TASK; LOCKED-IN SYNDROME; VEGETATIVE STATE; RECOGNITION MEMORY; EPISODIC RETRIEVAL; PREFRONTAL CORTEX; SEMANTIC MEMORY; BRAIN RESPONSE;

D O I：

10.1016/j.clinph.2011.03.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Although behavioral evaluation of awareness in disorders of consciousness is difficult it remains the clinical standard. We believe that the refinement of EEG and analyses techniques would improve our characterization of those patients. Methods: We focused on cognitive processing in a sample of 12 control subjects, eight vegetative-state patients, and 13 patients in the minimally consciousness state using EEG. We used an 'active paradigm' which asks subjects to follow instructions, specifically to actively count own or other names as compared to passively listening to them. EEG data was then analyzed using an advanced EEG analysis technique. Results: Results revealed that all groups exhibit a stronger theta-synchronization to their own names when forced to count them. We also observed a delay in theta power in response to targets relative to non-targets when participants were instructed to count their own name. Conclusion: Active paradigms are able to induce a different oscillatory activity compared to passive paradigms. Differences between controls and the pathologic groups are prominent in the theta-and alpha-band. Significance: Time-frequency analyses allow to focus on distinct cognitive processes in patients with disorders of consciousness and thereby contribute to a refined understanding of severely brain-injured patients. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：2177 / 2184

页数：8

共 44 条

[1] Human anterior and frontal midline theta and lower alpha reflect emotionally positive state and internalized attention: high-resolution EEG investigation of meditation [J].