Spectral-Domain Phase Microscopy for Thickness Encoded Suspension Array

被引：0

作者：

Guo, Cuixia ^{[1
,2
]}

Shen, Zhiyuan ^{[2
]}

Suo, Yanyan ^{[3
]}

Wu, Jian-Ping ^{[4
,5
]}

Zhou, Xuesi ^{[2
]}

Guan, Tian ^{[2
]}

Chen, Xuejing ^{[1
,2
]}

Zhong, Suyi ^{[2
]}

Ji, Yanhong ^{[6
]}

He, Yonghong ^{[2
]}

Chen, Fangyi ^{[5
]}

机构：

[1] Tsinghua Univ, Dept Phys, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Minimal Invas Med Technol, Shenzhen 518055, Peoples R China

[3] Shenzhen Entry Exit Inspect & Quarantine Bur, Shenzhen 518033, Peoples R China

[4] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China

[5] Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China

[6] South China Normal Univ, Sch Phys & Telecommun Engn, Guangzhou 510631, Peoples R China

来源：

IEEE PHOTONICS TECHNOLOGY LETTERS | 2020年 / 32卷 / 08期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Optical coherence tomography; spectral-domain phase microscopy; fluorescence microscopy; suspension array;

D O I：

10.1109/LPT.2020.2971508

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A system containing spectral-domain phase microscopy and fluorescence microscopy has been developed to decode and detect thickness-encoded suspension arrays. The spectral-domain phase imaging path is used for decoding the thickness of the micro glass pieces while the fluorescence imaging path is used for quantifying the targeted analytes. The spectral-domain phase microscopy uses a spectral domain phase retrieval technique so that it has a high-dynamic thickness imaging range and submicron-scale thickness resolution, increasing the encoding efficiency and decoding precision. The thickness decoding capability of the system has been demonstrated by multiplexed immunoassay experiments. The quantitative analysis capability has been verified by concentration gradient experiments.

引用

页码：461 / 464

页数：4

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