Acyl hydrazides as peptoid sub-monomers

被引：39

作者：

Sarma, Bani Kanta ^{[1
,2
]}

Yousufuddin, Muhammed ^{[3
]}

Kodadek, Thomas ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA

[2] Scripps Res Inst, Dept Canc Biol, Jupiter, FL 33458 USA

[3] Univ Texas Arlington, Ctr Nanostruct Mat, Arlington, TX 76019 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 38期

关键词：

MASS-SPECTROMETRIC CHARACTERISTICS; SIDE-CHAINS; COMBINATORIAL LIBRARIES; CELL-PERMEABILITY; DRUG DISCOVERY; PEPTIDE; CONFORMATION; OLIGOMERS; FAMILY;

D O I：

10.1039/c1cc12750k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of acyl hydrazides as peptoid sub-monomers is investigated. We demonstrate here that azapeptoids derived entirely from acyl hydrazides can be made conveniently and efficiently using standard peptoid sub-monomer chemistry. Structural studies reveal that the main chain amide bond in these molecules predominantly adopts a trans conformation. A high-quality one bead one compound library of tetramers was made by split and pool synthesis and we found that the identity of the molecule on a single bead could be determined by tandem MALDI mass spectrometry.

引用

页码：10590 / 10592

页数：3

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