Sensing the impact of environment on small molecule differentiation of RNA sequences

被引：17

作者：

Eubanks, Christopher S. ^{[1
]}

Hargrove, Amanda E. ^{[1
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27708 USA

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 100期

关键词：

PATTERN-RECOGNITION; SENSOR ARRAY; AMINOGLYCOSIDE; SECONDARY; STABILIZATION; BINDING; IONS; SITE;

D O I：

10.1039/c7cc07157d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using pattern recognition of RNA with small molecules (PRRSM) with fluorescent RNA chemosensors and aminoglycosides, we reveal the impact of changing environmental conditions on the differentiation of a range of RNA structures as well as the ability to predict different sequence/size compositions of five canonical RNA motifs.

引用

收藏

页码：13363 / 13366

页数：4

相关论文

共 38 条

[1] Differentiation of Whole Bacterial Cells Based on High-Throughput Microarray Chip Printing and Infrared Microspectroscopic Readout [J].

Al-Khaldi, Sufian F. ;

Mossoba, Magdi M. ;

Burke, Tara L. ;

Fry, Frederick S. .

FOODBORNE PATHOGENS AND DISEASE, 2009, 6 (08) :1001-1007

[2] Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes [J].

Baird, Nathan J. ;

Inglese, James ;

Ferre-D'Amare, Adrian R. .

NATURE COMMUNICATIONS, 2015, 6

[3] Cross-validation as the objective function for variable-selection techniques [J].

Baumann, K .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2003, 22 (06) :395-406

[4] Tris-borate is a poor counterion for RNA: a cautionary tale for RNA folding studies [J].

Buchmueller, KL ;

Weeks, KM .

NUCLEIC ACIDS RESEARCH, 2004, 32 (22) :e184

[5] Humans Can Discriminate More than 1 Trillion Olfactory Stimuli [J].

Bushdid, C. ;

Magnasco, M. O. ;

Vosshall, L. B. ;

Keller, A. .

SCIENCE, 2014, 343 (6177) :1370-1372

[6] The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones [J].

Cech, Thomas R. ;

Steitz, Joan A. .

CELL, 2014, 157 (01) :77-94

[7] The Dimensions, Dynamics, and Relevance of the Mammalian Noncoding Transcriptome [J].

Deveson, Ira W. ;

Hardwick, Simon A. ;

Mercer, Tim R. ;

Mattick, John S. .

TRENDS IN GENETICS, 2017, 33 (07) :464-478

[8]

Efthymiou T., 2001, Current protocols in nucleic acid chemistry

[9] Small Molecule-Based Pattern Recognition To Classify RNA Structure [J].

Eubanks, Christopher S. ;

Forte, Jordan E. ;

Kapral, Gary J. ;

Hargrove, Amanda E. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (01) :409-416

[10] Improved microwave-assisted ligand-free Suzuki-Miyaura cross-coupling of 5-iodo-2′-deoxyuridine in pure water [J].

Gallagher-Duval, Shawn ;

Herve, Gwenaelle ;

Sartori, Guillaume ;

Enderlin, Gerald ;

Len, Christophe .

NEW JOURNAL OF CHEMISTRY, 2013, 37 (07) :1989-1995

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