Physical chemical properties of oral drug candidates in the discovery and exploratory development settings

被引:174
作者
Curatolo, W [1 ]
机构
[1] Pfizer Inc, Cent Res, Groton, CT 06340 USA
来源
PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY | 1998年 / 1卷 / 09期
关键词
D O I
10.1016/S1461-5347(98)00097-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The advent of automated in vitro screening of hundreds of thousands of compounds has introduced biases into the drug discovery process that have significant implications for subsequent drug development. Screening biases that impact oral absorption adversely are discussed, and approaches are suggested for the prediction, assessment and communication of absorption-related physical chemical properties in drug discovery and exploratory development.
引用
收藏
页码:387 / 393
页数:7
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