Chiral N-phosphonyl imine chemistry:: new reagents and their applications for asymmetric reactions

被引：72

作者：

Kattuboina, Adiseshu ^{[1
]}

Li, Guigen ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 10期

关键词：

phosphoramide; N-phosphonyl imines; aziridine; aza-Darzens reaction; aza-Henry reaction; C(2)-symmetric diamine;

D O I：

10.1016/j.tetlet.2008.01.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel chiral N-phosphonyl imines 2 have been designed and synthesized using chiral N-phosphoramide 1. These N-phosphonyl imines have been successfully utilized for asymmetric aza-Darzens reaction and asymmetric aza-Henry reaction. The C(2)-symmetric chiral auxiliary tolerates oxidation, is not sensitive to racemization and can be recycled for large scale synthesis. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1573 / 1577

页数：5

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