Co-opting Moore's law: Therapeutics, vaccines and interfacially active particles manufactured via PRINT®

被引：28

作者：

DeSimone, Joseph M. ^{[1
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机构：

[1] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Lineberger Comprehens Canc Ctr,Dept Chem, Chapel Hill, NC 27599 USA

[2] NC State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA

[3] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst Canc Res, New York, NY 10021 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2016年 / 240卷

关键词：

Nanoparticle; PRINT; cGMP delivery vehicle; Liquidia technologies; Team-based science; Clinical trials; Particle engineering; Drug delivery vehicle; Particulate vaccine; Calibration quality particles; NANOPARTICLES; SHAPE; DESIGN; MONODISPERSE; FABRICATION; PLATFORM; SIZE;

D O I：

10.1016/j.jconrel.2016.07.019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanoparticle properties such as size, shape, deformability, and surface chemistry all play a role in nanomedicine drug delivery. While many studies address the behavior of particle systems in a biological setting, revealing how these properties work together presents unique challenges on the nanoscale. Particle replication in non-wetting templates (PRINT (R)) is one molding technique that allows for fabrication of "calibration quality" micro and nano-particles with independent control over their physical parameters. As the only technology in the world capable of independently optimizing and robustly manufacturing GMP compliant precision particles of virtually any size, shape, and composition, the PRINT technology has the capability to engineer the future of healthcare. (C) 2016 Published by Elsevier B.V.

引用

页码：541 / 543

页数：3

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