The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study

被引：37

作者：

Baskaran, Anusha ^{[1
,22
]}

Farzan, Faranak ^{[2
,4
,23
]}

Milev, Roumen ^{[1
,3
]}

Brenner, Colleen A. ^{[5
]}

Alturi, Sravya ^{[3
]}

McAndrews, Mary Pat ^{[6
]}

Blier, Pierre ^{[7
]}

Evans, Ken ^{[8
]}

Foster, Jane A. ^{[6
,9
,21
]}

Frey, Benicio N. ^{[10
,11
,12
]}

Giacobbe, Peter ^{[4
,13
]}

Lam, Raymond W. ^{[14
]}

Leri, Francesco ^{[15
]}

MacQueen, Glenda M. ^{[16
]}

Muller, Daniel J. ^{[4
,17
]}

Parikh, Sagar V. ^{[18
]}

Rotzinger, Susan ^{[4
,13
,21
]}

Soares, Claudio N. ^{[3
,21
]}

Strother, Steven C. ^{[19
]}

Turecki, Gustavo ^{[20
]}

Kennedy, Sidney H. ^{[4
,13
,21
]}

机构：

[1] Queens Unviersty, Ctr Neurosci Studies, Kingston, ON, Canada

[2] Ctr Addict & Mental Hlth, Temerty Ctr Therapeut Brain Intervent, Toronto, ON, Canada

[3] Queens Univ, Dept Psychiat, Kingston, ON, Canada

[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[5] Loma Linda Univ, Dept Psychol, Loma Linda, CA 92350 USA

[6] Univ Hlth Network, Krembil Res Inst, Toronto, ON, Canada

[7] Univ Ottawa, Brain & Mind Res Inst, Ottawa, ON, Canada

[8] Indoc Res, Toronto, ON, Canada

[9] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

[10] McMaster Univ, Psychiat & Behav Neurosci, Hamilton, ON, Canada

[11] St Josephs Healthcare, Mood Disorders Program, Hamilton, ON, Canada

[12] St Josephs Healthcare, Womens Hlth Concerns Clin, Hamilton, ON, Canada

[13] Univ Hlth Network, Dept Psychiat, Toronto, ON, Canada

[14] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada

[15] Univ Guelph, Dept Psychol, Guelph, ON, Canada

[16] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[17] Ctr Addict & Mental Hlth, Pharmacogenet Res Clin, Toronto, ON, Canada

[18] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[19] Baycrest, Rotman Res Inst, Toronto, ON, Canada

[20] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[21] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada

[22] Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON, Canada

[23] Simon Fraser Univ, Sch Mechatron Syst Engn, Surrey, BC, Canada

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2018年 / 227卷

基金：

加拿大健康研究院;

关键词：

EEG power; Alpha asymmetry; Theta cordance; Depression; Escitalopram; MAJOR DEPRESSION; ANTIDEPRESSANT RESPONSE; BRAIN ACTIVITY; EEG; DISORDER; BIOMARKERS; CORDANCE; POWER; NEUROBIOLOGY; METABOLISM;

D O I：

10.1016/j.jad.2017.10.028

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: This study aims to compare the effectiveness of EEG frequency band activity including interhemispheric asymmetry and prefrontal theta cordance in predicting response to escitalopram therapy at 8-weeks post-treatment, in a multi-site initiative. Methods: Resting state 64-channel EEG data were recorded from 44 patients with a diagnosis of major depressive disorder (MDD) as part of a larger, multisite discovery study of biomarkers in antidepressant treatment response, conducted by the Canadian Biomarker Integration Network in Depression (CAN-BIND). Clinical response was measured at 8-weeks post-treatment as change from baseline Montgomery-Asberg Depression Rating Scale (MADRS) score of 50% or more. EEG measures were analyzed at (1) pre-treatment baseline (2) 2 weeks post-treatment and (3) as an "early change" variable defined as change in EEG from baseline to 2 weeks posttreatment. Results: At baseline, treatment responders showed elevated absolute alpha power in the left hemisphere while non-responders showed the opposite. Responders further exhibited a cortical asymmetry in the parietal region. Groups also differed in pre-treatment relative delta power with responders showing greater power in the right hemisphere over the left while non-responders showed the opposite. At 2 weeks post-treatment, responders exhibited greater absolute beta power in the left hemisphere relative to the right and the opposite was noted for non-responders. A reverse pattern was noted for absolute and relative delta power at 2 weeks post-treatment. Responders exhibited early reductions in relative alpha power and early increments in relative theta power. Non-responders showed a significant early increase in prefrontal theta cordance. Conclusions: Hemispheric asymmetries in the alpha and delta bands at baseline and at 2 weeks post-treatment have moderately strong predictive utility in predicting response to antidepressant treatment.

引用

页码：542 / 549

页数：8

共 49 条

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