Application of 3D printed tools for customized open port probe-electrospray mass spectrometry

被引：17
作者：
Sosnowski, Piotr [1 ]
Hopfgartner, Gerard [1 ]
机构：
[1] Univ Geneva, Dept Inorgan & Analyt Chem, Life Sci Mass Spectrometry, Quai Ernest Ansermet 24, CH-1211 Geneva, Switzerland
来源：
TALANTA | 2020年 / 215卷 / 215期
关键词：
Open port probe; Mass spectrometry; Electrospray; Direct analysis; 3D printing; Fused deposition modeling; Stereolithography; SAMPLING INTERFACE; HUMAN PLASMA; IONIZATION; ONLINE; QUANTITATION; QUANTIFICATION; COCAINE; BRAIN; MS;
D O I：
10.1016/j.talanta.2020.120894
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Three dimensional printed open port probe (3DP-OPP) and air displacement based liquid handler, were designed and optimized using fused deposition modeling (FDM) and stereolitography (SLA) 3D printing. The performance of the devices were investigated for the analysis of solid and liquid samples with electrospray ionization mass spectrometry (ESI-MS). Direct analysis in less than 1 min and without any sample preparation, enabled detection of pesticides (azoxtystrobin/imazalil) on fruits peel surface and illegal substances (MDMA/MDEA) in homemade pills. Conjunction of OPP in the overspill mode with a customized autosampler, equipped with disposable pipette tips, enables direct quantitative analysis of drugs of abuse in urine and plasma, with minimized carryover and reduced matrix effect compared to flow injection analysis.
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页数：8
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