Improved Survival Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Treated With Remdesivir and Dexamethasone. A Nationwide Population-Based Cohort Study

被引：59

作者：

Benfield, Thomas ^{[1
,2
]}

Bodilsen, Jacob ^{[3
]}

Brieghel, Christian ^{[4
]}

Harboe, Zitta Barrella ^{[2
,5
]}

Helleberg, Marie ^{[6
]}

Holm, Claire ^{[7
]}

Israelsen, Simone Bastrup ^{[1
]}

Jensen, Janne ^{[8
]}

Jensen, Tomas Ostergaard ^{[6
]}

Johansen, Isik Somuncu ^{[9
]}

Johnsen, Stine ^{[7
]}

Lindegaard, Birgitte ^{[2
,6
]}

Lundgren, Jens ^{[2
,6
,10
]}

Meyer, Christian Niels ^{[11
]}

Mohey, Rajesh ^{[12
]}

Pedersen, Lars Moller ^{[7
]}

Nielsen, Henrik ^{[3
]}

Nielsen, Stig Lonberg ^{[9
]}

Obel, Niels ^{[2
,6
]}

Omland, Lars Haukali ^{[6
]}

Podlekareva, Daria ^{[7
]}

Poulsen, Birgitte Klindt ^{[13
]}

Ravn, Pernille ^{[4
]}

Sandholdt, Haakon ^{[1
]}

Starling, Jonathan ^{[6
]}

Storgaard, Merete ^{[14
]}

Soborg, Christian ^{[4
]}

Sogaard, Ole Schmeltz ^{[14
]}

Tranborg, Torben ^{[15
]}

Wiese, Lothar ^{[11
]}

Christensen, Hanne Rolighed ^{[16
]}

机构：

[1] Copenhagen Univ Hosp, Ctr Res & Disrupt Infect Dis, Dept Infect Dis, Kettegaard Alle 30, DK-2650 Hvidovre, Denmark

[2] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[3] Aalborg Univ Hosp, Dept Infect Dis, Aalborg, Denmark

[4] Copenhagen Univ Hosp, Dept Infect Dis, Herlev, Denmark

[5] Copenhagen Univ Hosp, Dept Resp Med & Infect Dis, North Zealand, Denmark

[6] Copenhagen Univ Hosp, Rigshosp, Dept Infect Dis, Copenhagen, Denmark

[7] Copenhagen Univ Hosp, Dept Resp Med, Copenhagen, Denmark

[8] Kolding Cty Hosp, Dept Med, Kolding, Denmark

[9] Univ Southern Denmark, Odense Univ Hosp, Res Unit Infect Dis, Odense, Denmark

[10] Copenhagen Univ Hosp, Rigshosp, CHIP, Copenhagen, Denmark

[11] Zealand Univ Hosp, Dept Med, Roskilde, Denmark

[12] Herning Hosp, Dept Med, Herning, Denmark

[13] Aalborg Univ Hosp, Dept Clin Pharmacol, Aalborg, Denmark

[14] Aarhus Univ Hosp, Dept Infect Dis, Aarhus, Denmark

[15] Esbjerg Cent Hosp, Dept Med, Esbjerg, Denmark

[16] Copenhagen Univ Hosp, Dept Clin Pharmacol, Copenhagen, Denmark

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 73卷 / 11期

关键词：

COVID-19; pneumonia; remdesivir; dexamethasone; survival;

D O I：

10.1093/cid/ciab536

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. There are limited data on outcomes of moderate to severe coronavirus disease 2019 (COVID-19) among patients treated with remdesivir and dexamethasone in a real-world setting. We sought to compare the effectiveness of standard of care (SOC) alone versus SOC plus remdesivir and dexamethasone. Methods. Two population-based nationwide cohorts of individuals hospitalized with COVID-19 during February through December 2020 were studied. Death within 30 days and need of mechanical ventilation (MV) were compared by inverse probability of treatment weighted (ITPW) logistic regression analysis and shown as odds ratio (OR) with 95% confidence interval (CI). Results. The 30-days mortality rate of 1694 individuals treated with remdesivir and dexamethasone in addition to SOC was 12.6% compared to 19.7% for 1053 individuals receiving SOC alone. This corresponded to a weighted OR of 30-day mortality of 0.47 (95% CI:.38-.57) for patients treated with remdesivir and dexamethasone compared to patients receiving SOC alone. Similarly, progression to MV was reduced (OR 0.36; 95% CI:.29-.46). Conclusions. Treatment of moderate to severe COVID-19 during June through December that included remdesivir and dexamethasone was associated with reduced 30-day mortality and need of MV compared to treatment in February through May.

引用

页码：2031 / 2036

页数：6

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