Regulatory T-cell therapy in Crohn's disease: challenges and advances

被引：117

作者：

Clough, Jennie N. ^{[1
,2
,3
]}

Omer, Omer S. ^{[1
,4
]}

Tasker, Scott ^{[5
]}

Lord, Graham M. ^{[1
,6
]}

Irving, Peter M. ^{[1
,4
]}

机构：

[1] Kings Coll London, Sch Immunol & Microbial Sci, London, England

[2] Guys & St Thomas NHS Fdn Trust, NIHR Biomed Res Ctr, London, England

[3] Kings Coll London, London, England

[4] Guys & St Thomas Hosp NHS Trust, Dept Gastroenterol, London, England

[5] Kings Coll London, Div Transplantat Immunol & Mucosal Biol, London, England

[6] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England

来源：

GUT | 2020年 / 69卷 / 05期

基金：

英国医学研究理事会;

关键词：

INFLAMMATORY-BOWEL-DISEASE; EX-VIVO; IMMUNE DYSREGULATION; SELF-TOLERANCE; DIFFERENTIAL EXPRESSION; SUPPRESSIVE FUNCTION; ALLOGRAFT-REJECTION; ADOPTIVE TRANSFER; DENDRITIC CELLS; RETINOIC-ACID;

D O I：

10.1136/gutjnl-2019-319850

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T cells in immune homeostasis, with defects in number and suppressive function of regulatory T cells seen in patients with Crohn's disease. We review the function of regulatory T cells and the pathways by which they exert immune tolerance in the intestinal mucosa. We explore the principles and challenges of manufacturing a cell therapy, and discuss clinical trial evidence to date for their safety and efficacy in human disease, with particular focus on the development of a regulatory T-cell therapy for Crohn's disease.

引用

页码：942 / 952

页数：11

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