Effects of stress and etifoxine on pentobarbital-induced loss of righting reflex in Balb/cByJ and C57BL/6J mice

被引：11
作者：
Verleye, M [1 ]
Heulard, I
Nuss, P
Gillardin, JM
机构：
[1] Zac Mercieres, Lab Biocodex, Dept Pharmacol, F-60200 Compiegne, France
[2] Hop St Antoine, Dept Psychiat & Psychol Med, F-75571 Paris, France
来源：
NEUROSCIENCE LETTERS | 2003年 / 353卷 / 02期
关键词：
inbred mice strains; BALB/cByJ mouse; C57BL/6J mouse; pentobarbital-induced loss of righting reflex; GABAergic system; etifoxine; stress;
D O I：
10.1016/j.neulet.2003.09.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We hypothesized that functional changes in the GABAergic system induced by stress would differ between two inbred mouse strains BALB/cByJ and C57BL/6J. We compared the effects of restraint stress and of the anxiolytic drug etifoxine (EFX) on the duration of pentobarbital-induced loss of righting reflex (hypnotic effect) in the two strains. Naive BALB/cByJ mice were less sensitive than naive C57BL/6J mice to the hypnotic effect of pentobarbital. C57BL/6J mice exhibited a shortening in the duration of pentobarbital-induced hypnosis following stress whereas stress had no effect in BALB/cByJ mice. EFX reversed the shortening of pentobarbital-induced hypnosis elicited by stress in C57BL/6J and shortened the duration of pentobarbital-induced hypnosis after stress in BALB/cByJ mice. Alterations in the GABAergic function in BALB/cByJ mice could be corrected by EFX, an enhancer of GABAergic transmission. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：127 / 130
页数：4
相关论文
共 20 条
  • [1] Ågmo A, 1999, PSYCHOBIOLOGY, V27, P105
  • [2] Measuring normal and pathological anxiety-like behaviour in mice: a review
    Belzung, C
    Griebel, G
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2001, 125 (1-2) : 141 - 149
  • [3] Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety
    Belzung, C
    Berton, F
    [J]. BEHAVIOURAL PHARMACOLOGY, 1997, 8 (6-7): : 541 - 548
  • [4] GABAERGIC AND DOPAMINERGIC TRANSMISSION IN THE RAT CEREBRAL-CORTEX - EFFECT OF STRESS, ANXIOLYTIC AND ANXIOGENIC DRUGS
    BIGGIO, G
    CONCAS, A
    CORDA, MG
    GIORGI, O
    SANNA, E
    SERRA, M
    [J]. PHARMACOLOGY & THERAPEUTICS, 1990, 48 (02) : 121 - 142
  • [5] BOISSIER JR, 1972, THERAPIE, V27, P325
  • [6] Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice
    Carola, V
    D'Olimpio, F
    Brunamonti, E
    Mangia, F
    Renzi, P
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2002, 134 (1-2) : 49 - 57
  • [7] GENETIC DIFFERENCE IN SENSITIVITY TO BETA-CARBOLINE - EVIDENCE FOR THE INVOLVEMENT OF BRAIN BENZODIAZEPINE RECEPTORS
    CHAPOUTHIER, G
    BONDOUX, D
    MARTIN, B
    DESFORGES, C
    LAUNAY, JM
    [J]. BRAIN RESEARCH, 1991, 553 (02) : 342 - 346
  • [8] Genetic basis of anxiety-like behaviour:: A critical review
    Clément, Y
    Calatayud, F
    Belzung, C
    [J]. BRAIN RESEARCH BULLETIN, 2002, 57 (01) : 57 - 71
  • [9] DIVERSITY OF UNDERLYING MECHANISMS IN THE PRODUCTION OF ANALGESIC AND PENTOBARBITAL-HYPNOSIS PROLONGING EFFECTS OF VARIOUS ANALGESIC DRUGS AND STRESSES
    HANADA, S
    DEGUCHI, Y
    KANETO, H
    [J]. JAPANESE JOURNAL OF PHARMACOLOGY, 1985, 39 (01) : 117 - 119
  • [10] DIFFERENCE IN THE REACTIVITY OF THE MESOCORTICAL DOPAMINERGIC-NEURONS TO STRESS IN THE BALB-C AND C57 BL-6 MICE
    HERVE, D
    TASSIN, JP
    BARTHELEMY, C
    BLANC, G
    LAVIELLE, S
    GLOWINSKI, J
    [J]. LIFE SCIENCES, 1979, 25 (19) : 1659 - 1664
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