Anethole and Its Role in Chronic Diseases

被引：88
作者：
Aprotosoaie, Ana Clara [1 ]
Costache, Irina-Iuliana [2 ]
Miron, Anca [1 ]
机构：
[1] Univ Med & Pharm Grigore T Popa, Fac Pharm, Dept Pharmacognosy, Iasi, Romania
[2] Univ Med & Pharm Grigore T Popa, Sf Spiridon Univ Hosp Iasi, Fac Med, Dept Internal Med, Iasi, Romania
来源：
DRUG DISCOVERY FROM MOTHER NATURE | 2016年 / 929卷
关键词：
Anethole; Anti-inflammatory; Anticarcinogenic; NF-kB; TNF-alpha; MAPK; STAT; AP-1 signaling pathways; CROTON-ZEHNTNERI LEAVES; NF-KAPPA-B; TRANS-ANETHOLE; ESSENTIAL OIL; CHEMICAL-COMPOSITION; INDUCED APOPTOSIS; ILLICIUM-VERUM; RAT; ANTIOXIDANT; METABOLISM;
D O I：
10.1007/978-3-319-41342-6_11
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Anethole is the main fragrance and bioactive compound of anise, fennel, and star anise spices and more than other 20 plant species. It is widely used as flavor agent in food industry and other industries, in cosmetics, perfumery, and pharmaceuticals. In the last few years, various studies have revealed multiple beneficial effects of anethole for human health, such as anti-inflammatory, anti-carcinogenic and chemopreventive, antidiabetic, immunomodulatory, neuroprotective, or antithrombotic, that are mediated by the modulation of several cell signaling pathways, mainly NF-kB and TNF-alpha signaling, and various ion channels. This chapter aims to review the scientific data and attempts to provide an insight into pharmacological activity of anethole and its therapeutic potential in human chronic diseases.
引用
收藏
页码：247 / 268
页数：22
相关论文
共 83 条
[21]  
de las Heras B., 2009, Inflammation & Allergy Drug Targets, V8, P28
[22]  
De Rovira Sr D., 2008, DICT FLAVORS, V2nd
[23]   Cardiovascular effects of the essential oil of Croton zehntneri leaves and its main constituents, anethole and estragole, in normotensive conscious rats [J].
de Siqueira, RJB ;
Magalhaes, PJC ;
Leal-Cardoso, JH ;
Duarte, GP ;
Lahlou, S .
LIFE SCIENCES, 2006, 78 (20) :2365-2372
[24]   Role of capsaicin-sensitive sensory nerves in mediation of the cardiovascular effects of the essential oil of Croton zehntneri leaves in anaesthetized rats [J].
de Siqueira, RJB ;
Leal-Cardoso, JH ;
Couture, R ;
Lahlou, S .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2006, 33 (03) :238-247
[25]   Inhibitory effect of anethole in nonimmune acute inflammation [J].
Domiciano, Talita Perdigao ;
de Oliveira Dalalio, Marcia Machado ;
Silva, Expedito Leite ;
Versuti Ritter, Alessandra Mileni ;
Estevao-Silva, Camila Fernanda ;
Ramos, Fernando Seara ;
Caparroz-Assef, Silvana Martins ;
Nakamura Cuman, Roberto Kenji ;
Bersani-Amado, Ciomar Aparecida .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2013, 386 (04) :331-338
[26]   Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits [J].
Dongare, Vandana ;
Kulkarni, Chaitanya ;
Kondawar, Manish ;
Magdum, Chandrakant ;
Haldavnekar, Vivek ;
Arvindekar, Akalpita .
FOOD CHEMISTRY, 2012, 132 (01) :385-390
[27]   The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes [J].
Drukarch, B ;
Flier, J ;
Jongenelen, CAM ;
Andringa, G ;
Schoffelmeer, ANM .
JOURNAL OF NEURAL TRANSMISSION, 2006, 113 (05) :593-598
[28]   Chemical composition and antifungal activity of Illicium verum and Eugenia caryophyllata essential oils [J].
Dzamic, Ana ;
Sokovic, Marina ;
Ristic, Mihailo S. ;
Grijic-Jovanovic, Slavica ;
Vukojevic, Jelena ;
Marin, Petar D. .
CHEMISTRY OF NATURAL COMPOUNDS, 2009, 45 (02) :259-261
[29]   Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB4, and carrageenan [J].
Estevao-Silva, Camila Fernanda ;
Kummer, Raquel ;
Fachini-Queiroz, Fernanda Carolina ;
Grespan, Renata ;
Nogueira de Melo, Gessilda Alcantara ;
Baroni, Silmara ;
Nakamura Cuman, Roberto Kenji ;
Bersani-Amado, Ciomar Aparecida .
JOURNAL OF NATURAL MEDICINES, 2014, 68 (03) :567-575
[30]  
Food Chemical Codex, 2010, US PHARMACOPEIAL CON
123456789