Anethole and Its Role in Chronic Diseases

被引：88

作者：

Aprotosoaie, Ana Clara ^{[1
]}

Costache, Irina-Iuliana ^{[2
]}

Miron, Anca ^{[1
]}

机构：

[1] Univ Med & Pharm Grigore T Popa, Fac Pharm, Dept Pharmacognosy, Iasi, Romania

[2] Univ Med & Pharm Grigore T Popa, Sf Spiridon Univ Hosp Iasi, Fac Med, Dept Internal Med, Iasi, Romania

来源：

DRUG DISCOVERY FROM MOTHER NATURE | 2016年 / 929卷

关键词：

Anethole; Anti-inflammatory; Anticarcinogenic; NF-kB; TNF-alpha; MAPK; STAT; AP-1 signaling pathways; CROTON-ZEHNTNERI LEAVES; NF-KAPPA-B; TRANS-ANETHOLE; ESSENTIAL OIL; CHEMICAL-COMPOSITION; INDUCED APOPTOSIS; ILLICIUM-VERUM; RAT; ANTIOXIDANT; METABOLISM;

D O I：

10.1007/978-3-319-41342-6_11

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anethole is the main fragrance and bioactive compound of anise, fennel, and star anise spices and more than other 20 plant species. It is widely used as flavor agent in food industry and other industries, in cosmetics, perfumery, and pharmaceuticals. In the last few years, various studies have revealed multiple beneficial effects of anethole for human health, such as anti-inflammatory, anti-carcinogenic and chemopreventive, antidiabetic, immunomodulatory, neuroprotective, or antithrombotic, that are mediated by the modulation of several cell signaling pathways, mainly NF-kB and TNF-alpha signaling, and various ion channels. This chapter aims to review the scientific data and attempts to provide an insight into pharmacological activity of anethole and its therapeutic potential in human chronic diseases.

引用

页码：247 / 268

页数：22

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