Suppression of the notch signaling pathway by γ-secretase inhibitor GSI inhibits human nasopharyngeal carcinoma cell proliferation

被引：25

作者：

Chen, Shi-Ming ^{[1
,2
]}

Liu, Jun-Ping ^{[2
]}

Zhou, Jun-Xu ^{[1
]}

Chen, Chen ^{[1
]}

Deng, Yu-Qin ^{[1
]}

Wang, Yan ^{[1
]}

Tao, Ze-Zhang ^{[1
]}

机构：

[1] Wuhan Univ, Dept Otolaryngol Head & Neck Surg, Renmin Hosp, Wuhan 430060, Peoples R China

[2] Monash Univ, Mol Signaling Lab, Dept Immunol, Melbourne, Vic 3004, Australia

来源：

CANCER LETTERS | 2011年 / 306卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Notch; Nasopharyngeal carcinoma cells; GSI; Apoptosis; AKT; CANCER CELLS; JAGGED1; EXPRESSION; DOWN-REGULATION; BREAST-CANCER; CYCLE ARREST; APOPTOSIS; GROWTH; ACTIVATION; TRANSCRIPTION; CONTRIBUTES;

D O I：

10.1016/j.canlet.2011.02.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Notch signaling has been suggested to be required for many human cancers. However, the role of Notch signaling in human nasopharyngeal carcinoma cells (NPC) remains unknown. Here, we report that Notch-1, Notch-2, Notch-3 and Notch-4 are all detected in NPC cells. Notch inhibitor, GSI, suppresses the levels of Notch-1. Notch-2 and Notch-4, but not Notch-3. In addition, GSI inhibits NPC cell proliferation by inducing the cell cycle arrest and apoptosis. Furthermore, GSI inhibits the AKT and MEK signaling, without affecting P38 and JNK1/2. Thus, NPC cells may up-regulate Notch signaling to maintain cell proliferation and targeting the Notch signaling pathway may offer a potential alternative strategy for the treatment of NPC. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：76 / 84

页数：9

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