Molecular cloning and characterization of monoamine oxidase A and B genes in pig

被引：3
作者：
Bai, CY
Meng, H
Zhao, W
Pan, YC
机构：
[1] Shanghai Jiao Tong Univ, Agr & Biol Coll, Dept Anim Sci, Shanghai 201101, Peoples R China
[2] NE Agr Univ, Sch Anim Sci, Dept Anim Breeding & Genet, Harbin, Heilongjiang Pr, Peoples R China
来源：
DNA SEQUENCE | 2005年 / 16卷 / 03期
关键词：
monoamine oxidase; pig; stress; cDNA;
D O I：
10.1080/10425170500097925
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Monoamine oxidase (MAO) is a key enzyme in the degradation of monoamine neurotransmitters, which are physiologically and pathologically important for animals and humans. MAO exists in two forms, coded by separate genes. Here we cloned and sequenced full length cDNAs of MAO-A and MAO-B in pig. The putative proteins include 527 and 520 amino acids, respectively. The sequences alignment and homology analysis showed that MAO- A and MAO- B are conserved among mammals. The amino acid residues and domains, which have been demonstrated to be important for MAO- A and MAO- B binding of ligands, substrates and inhibitors, were conserved in the pig.
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页码：161 / 165
页数：5
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