Ratiometric detection of cysteine by a ferrocenyl Michael acceptor

被引：25

作者：

Lim, Soo-Yeon ^{[1
]}

Kim, Hae-Jo ^{[1
]}

机构：

[1] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, South Korea

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 25期

关键词：

Cysteine; Ferrocene; Hydrogen bond; Naked-eye detection; CYANIDE DETECTION; GLUTATHIONE; DISEASE; WATER;

D O I：

10.1016/j.tetlet.2011.03.153

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An activated ferrocenyl enone (1) by an intramolecular hydrogen bond was utilized as a Michael acceptor type of chemodosimeter for cysteine. The probe has shown selective response toward cysteine over other natural amino acids through the Michael addition reaction of a cysteinyl thiol group to 1. When cysteine was added, the prominent color change of 1 was observed so that submillimolar concentrations of cysteine were detectable by the naked eye. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3189 / 3190

页数：2

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