Neuropsychiatric symptoms in Parkinson's disease: association with caregiver distress and disease severity

被引：9

作者：

Tsai, Wan-Chen ^{[1
,2
]}

Lin, Hui-Chen ^{[1
,2
]}

Chang, Chiung-Chih ^{[1
,2
]}

Chang, Wen-Neng ^{[1
,2
]}

Huang, Chih-Cheng ^{[1
,2
]}

Cheng, Kuei-Yueh ^{[2
,3
]}

Wang, Hung-Chen ^{[2
,4
]}

Lin, Wei-Che ^{[2
,5
]}

Hsiao, Sheng-Yuan ^{[2
,6
,7
]}

Lai, Yun-Ru ^{[1
,2
,7
]}

Lu, Cheng-Hsien ^{[1
,2
,7
]}

Tsai, Nai-Wen ^{[1
,2
]}

机构：

[1] Kaohsiung Chang Gung Mem Hosp, Dept Neurol, Kaohsiung, Taiwan

[2] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan

[3] Kaohsiung Chang Gung Mem Hosp, Dept Nursing, Kaohsiung, Taiwan

[4] Kaohsiung Chang Gung Mem Hosp, Dept Neurosurg, Kaohsiung, Taiwan

[5] Kaohsiung Chang Gung Mem Hosp, Dept Radiol, Kaohsiung, Taiwan

[6] Kaohsiung Chang Gung Mem Hosp, Dept Emergency Med, Kaohsiung, Taiwan

[7] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung, Taiwan

来源：

INTERNATIONAL PSYCHOGERIATRICS | 2020年 / 32卷 / 06期

关键词：

Parkinson's disease; distress; neuropsychiatric inventory; dementia; ABILITIES SCREENING INSTRUMENT; QUALITY-OF-LIFE; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; NONMOTOR SYMPTOMS; DEMENTIA; CHINESE; BURDEN; IMPACT; INVENTORY;

D O I：

10.1017/S1041610219001510

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Objectives: The condition of caregivers is important to the quality of care received by people with Parkinson's disease (PD), especially at the late disease stages. This study addresses the distress placed on caregivers by participants' neuropsychiatric symptoms at different stages of PD in Taiwan Methods: This prospective study enrolled 108 people with PD. All participants were examined with the Unified Parkinson's Disease Rating Scale (UPDRS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Cognitive Abilities Screening Instrument (CASI), and Clinical Dementia Rating (CDR) scale. Caregiver distress was measured using the Neuropsychiatric Inventory Caregiver Distress Scale (NPI-D). Statistical analysis was used to explore the PD-related factors that contribute to caregiver distress. Results: The mean follow-up interval in the 108 PD participants were 24.0 +/- 10.2 months with no participant lost to follow-up due to death. NPI-distress (the sum of NPI caregiver distress scale across the 12 domains of the NPI) was positively correlated with NPI-sum (the total score across the 12 domains of the NPI) (r= 0.787,p< 0.001), CDR (r= 0.403,p< 0.001), UPRDS (r= 0.276,p= 0.004), and disease duration (r= 0.246,p= 0.002), but negatively correlated with CASI (r= -0.237,p= 0.043) and MMSE (r= -0.281,p< 0.001). Multiple linear regression analysis showed that only NPI-sum and disease duration were independently correlated with NPI-distress. Conclusion: The disease duration and NPI-sum are independent predictors of caregiver distress in Taiwanese populations with PD. Early detection and reduction of neuropsychiatric symptoms in people with PD can help decrease caregiver distress.

引用

页码：733 / 739

页数：7

共 36 条

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