SENSITIVE METHOD FOR DETERMINATION OF PIPLARTINE, AN ALKALOID AMIDE FROM Piper SPECIES, IN RAT PLASMA SAMPLES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

被引：15

作者：

Bezerra, Daniel P. ^{[1
]}

Pessoa, Claudia ^{[1
]}

Moraes, Manoel O. ^{[1
]}

Costa-Lotufo, Leticia V. ^{[1
]}

Gouvea, Dayana Rubio ^{[2
]}

Polisel Jabor, Valquiria A. ^{[2
]}

Lopes, Norberto Peporine ^{[2
]}

Borges, Keyller Bastos ^{[3
]}

Lima, Mary Anne S. ^{[4
]}

Silveira, Edilberto R. ^{[4
]}

机构：

[1] Univ Fed Ceara, Fac Med, Dept Fisiol & Farmacol, BR-60430160 Fortaleza, Ceara, Brazil

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, BR-14040903 Ribeirao Preto, SP, Brazil

[3] Univ Fed Sao Joao del Rei, Dept Ciencias Nat, BR-36301160 Sao Joao Del Rei, MG, Brazil

[4] Univ Fed Ceara, Dept Quim Organ & Inorgan, BR-60451970 Fortaleza, Ceara, Brazil

来源：

QUIMICA NOVA | 2012年 / 35卷 / 03期

关键词：

piplartine; LC-MS/MS; rat plasma analysis; CYTOTOXIC PYRIDONE ALKALOIDS; ANTIFUNGAL AMIDES; NATURAL-PRODUCTS; TUBERCULATUM; CONSTITUENTS; INHIBITION; LONGUM; HERBS;

D O I：

10.1590/S0100-40422012000300004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Piplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better understand its biological effects. The aim of this study was to develop a sensitive LC-MS/MS method for the determination of PPTN in rat plasma. The performance criteria for linearity, sensitivity, precision, accuracy, recovery, and stability have been assessed and were within the recommended guidelines. The validated method proved to be suitable in a pilot study of PPTN kinetic disposition in rat plasma after a single intraperitoneal dose, and represents an appropriate tool to further pharmacokinetic studies.

引用

页码：460 / 465

页数：6

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