SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis

被引：58

作者：

Delpino, M. Victoria ^{[1
,2
]}

Quarleri, Jorge ^{[2
,3
]}

机构：

[1] Univ Buenos Aires, Inst Inmunol Genet & Metab INIGEM, Fac Farm & Bioquim, Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn CONICET, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires UBA, Inst Invest Biomed Retrovirus & Sida INBIRS, Fac Med, Buenos Aires, DF, Argentina

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2020年 / 10卷

关键词：

SARS-CoV-2; ACE2; Fibrosis; ANG1-7; Renin angiotensin system (RAS); CONVERTING ENZYME 2; TRANSFORMING GROWTH FACTOR-BETA1; SARS-COV; COLLAGEN I; EXPRESSION; RECEPTOR; BETA; MAS; FIBROBLASTS; PATHOLOGY;

D O I：

10.3389/fcimb.2020.00340

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页数：5

共 41 条

[1] Clinical and immunological features of severe and moderate coronavirus disease 2019 [J].

Chen, Guang ;

Wu, Di ;

Guo, Wei ;

Cao, Yong ;

Huang, Da ;

Wang, Hongwu ;

Wang, Tao ;

Zhang, Xiaoyun ;

Chen, Huilong ;

Yu, Haijing ;

Zhang, Xiaoping ;

Zhang, Minxia ;

Wu, Shiji ;

Song, Jianxin ;

Chen, Tao ;

Han, Meifang ;

Li, Shusheng ;

Luo, Xiaoping ;

Zhao, Jianping ;

Ning, Qin .

JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (05) :2620-2629

[2] Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies [J].

Cofre, Catalina ;

Jose Acuna, Maria ;

Contreras, Osvaldo ;

Gabriela Morales, Maria ;

Riquelme, Cecilia ;

Cabello-Verrugio, Claudio ;

Brandan, Enrique .

BIOFACTORS, 2015, 41 (02) :111-120

[3] Anti-Inflammatory Effects of the Activation of the Angiotensin-(1-7) Receptor, Mas, in Experimental Models of Arthritis [J].

da Silveira, Katia Daniela ;

Coelho, Fernanda Matos ;

Vieira, Angelica Thomaz ;

Sachs, Daniela ;

Barroso, Livia Correa ;

Costa, Vivian Vasconcelos ;

Bicalho Bretas, Thales Lages ;

Bader, Michael ;

de Sousa, Lirlandia Pires ;

da Silva, Tarcilia Aparecida ;

Souza dos Santos, Robson Augusto ;

Simoes e Silva, Ana Cristina ;

Teixeira, Mauro Martins .

JOURNAL OF IMMUNOLOGY, 2010, 185 (09) :5569-5576

[4] Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts [J].

Gao, Xiuren ;

He, Xuyu ;

Luo, Bing ;

Peng, Longyun ;

Lin, Jun ;

Zuo, Zhiyi .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 606 (1-3) :115-120

[5] Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells [J].

Gava, Elisandra ;

Samad-Zadeh, Arman ;

Zimpelmann, Joseph ;

Bahramifarid, Nasim ;

Kitten, Gregory T. ;

Santos, Robson A. ;

Touyz, Rhian M. ;

Burns, Kevin D. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (06) :1766-1773

[6] Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy [J].

George, Peter M. ;

Wells, Athol U. ;

Jenkins, R. Gisli .

LANCET RESPIRATORY MEDICINE, 2020, 8 (08) :807-815

[7] A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2 [J].

Grifoni, Alba ;

Sidney, John ;

Zhang, Yun ;

Scheuermann, Richard H. ;

Peters, Bjoern ;

Sette, Alessandro .

CELL HOST & MICROBE, 2020, 27 (04) :671-+

[8] Asthma: a simple concept but in reality a complex disease [J].

Holgate, Stephen T. .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2011, 41 (12) :1339-1352

[9] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].

Huang, Chaolin ;

Wang, Yeming ;

Li, Xingwang ;

Ren, Lili ;

Zhao, Jianping ;

Hu, Yi ;

Zhang, Li ;

Fan, Guohui ;

Xu, Jiuyang ;

Gu, Xiaoying ;

Cheng, Zhenshun ;

Yu, Ting ;

Xia, Jiaan ;

Wei, Yuan ;

Wu, Wenjuan ;

Xie, Xuelei ;

Yin, Wen ;

Li, Hui ;

Liu, Min ;

Xiao, Yan ;

Gao, Hong ;

Guo, Li ;

Xie, Jungang ;

Wang, Guangfa ;

Jiang, Rongmeng ;

Gao, Zhancheng ;

Jin, Qi ;

Wang, Jianwei ;

Cao, Bin .

LANCET, 2020, 395 (10223) :497-506

[10] Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects [J].

Iwata, M ;

Cowling, RT ;

Gurantz, D ;

Moore, C ;

Zhang, S ;

Yuan, JXJ ;

Greenberg, BH .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2005, 289 (06) :H2356-H2363

← 1 2 3 4 5 →