INVESTIGATING STRIATAL FUNCTION THROUGH CELL-TYPE-SPECIFIC MANIPULATIONS

被引：42

作者：

Kreitzer, A. C. ^{[1
,2
,3
]}

Berke, J. D. ^{[4
,5
,6
]}

机构：

[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA

[4] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Program Neurosci, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Movement Disorders Program, Ann Arbor, MI 48109 USA

来源：

NEUROSCIENCE | 2011年 / 198卷

关键词：

striatum; BAC transgenic; optogenetics; medium spiny neuron; cholinergic interneuron; fast-spiking interneuron; MEDIUM SPINY NEURONS; BASAL GANGLIA; DOPAMINE-D2; RECEPTORS; TARGETED EXPRESSION; OPTOGENETIC CONTROL; INDIRECT PATHWAYS; GENE-EXPRESSION; TOXIN GENE; D1; COCAINE;

D O I：

10.1016/j.neuroscience.2011.08.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The striatum integrates convergent input from the codex, thalamus, and midbrain, and has a powerful influence over motivated behavior via outputs to downstream basal ganglia nuclei. Although the anatomy and physiology of distinct classes of striatal neurons have been intensively studied, the specific functions of these cell subpopulations have been more difficult to address. Recently, application of new methodologies for perturbing activity and signaling in different cell types in vivo has begun to allow direct tests of the causal roles of striatal neurons in behavior. This article is part of a Special Issue entitled: Function and Dysfunction of the Basal Ganglia. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：19 / 26

页数：8

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