INVESTIGATING STRIATAL FUNCTION THROUGH CELL-TYPE-SPECIFIC MANIPULATIONS

被引：42
作者：
Kreitzer, A. C. [1 ,2 ,3 ]
Berke, J. D. [4 ,5 ,6 ]
机构：
[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA
[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA
[4] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Program Neurosci, Ann Arbor, MI 48109 USA
[6] Univ Michigan, Movement Disorders Program, Ann Arbor, MI 48109 USA
来源：
NEUROSCIENCE | 2011年 / 198卷
关键词：
striatum; BAC transgenic; optogenetics; medium spiny neuron; cholinergic interneuron; fast-spiking interneuron; MEDIUM SPINY NEURONS; BASAL GANGLIA; DOPAMINE-D2; RECEPTORS; TARGETED EXPRESSION; OPTOGENETIC CONTROL; INDIRECT PATHWAYS; GENE-EXPRESSION; TOXIN GENE; D1; COCAINE;
D O I：
10.1016/j.neuroscience.2011.08.018
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The striatum integrates convergent input from the codex, thalamus, and midbrain, and has a powerful influence over motivated behavior via outputs to downstream basal ganglia nuclei. Although the anatomy and physiology of distinct classes of striatal neurons have been intensively studied, the specific functions of these cell subpopulations have been more difficult to address. Recently, application of new methodologies for perturbing activity and signaling in different cell types in vivo has begun to allow direct tests of the causal roles of striatal neurons in behavior. This article is part of a Special Issue entitled: Function and Dysfunction of the Basal Ganglia. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：19 / 26
页数：8
相关论文
共 89 条
[1]   THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].
ALBIN, RL ;
YOUNG, AB ;
PENNEY, JB .
TRENDS IN NEUROSCIENCES, 1989, 12 (10) :366-375
[2]   Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand [J].
Armbruster, Blaine N. ;
Li, Xiang ;
Pausch, Mark H. ;
Herlitze, Stefan ;
Roth, Bryan L. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (12) :5163-5168
[3]   Separate neural substrates for skill learning and performance in the ventral and dorsal striatum [J].
Atallah, Hisham E. ;
Lopez-Paniagua, Dan ;
Rudy, Jerry W. ;
O'Reilly, Randall C. .
NATURE NEUROSCIENCE, 2007, 10 (01) :126-131
[4]   PARKINSONIAN-LIKE LOCOMOTOR IMPAIRMENT IN MICE LACKING DOPAMINE D2 RECEPTORS [J].
BAIK, JH ;
PICETTI, R ;
SAIARDI, A ;
THIRIET, G ;
DIERICH, A ;
DEPAULIS, A ;
LEMEUR, M ;
BORRELLI, E .
NATURE, 1995, 377 (6548) :424-428
[5]   Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors [J].
Bateup, Helen S. ;
Santini, Emanuela ;
Shen, Weixing ;
Birnbaum, Shari ;
Valjent, Emmanuel ;
Surmeier, D. James ;
Fisone, Gilberto ;
Nestler, Eric J. ;
Greengard, Paul .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) :14845-14850
[6]   ASSOCIATION OF DOPAMINE-D1 AND DOPAMINE-D2 RECEPTORS WITH SPECIFIC CELLULAR-ELEMENTS IN THE BASAL GANGLIA OF THE CAT - THE UNEVEN TOPOGRAPHY OF DOPAMINE-RECEPTORS IN THE STRIATUM IS DETERMINED BY INTRINSIC STRIATAL CELLS, NOT NIGROSTRIATAL AXONS [J].
BECKSTEAD, RM .
NEUROSCIENCE, 1988, 27 (03) :851-863
[7]   Fast oscillations in cortical-striatal networks switch frequency following rewarding events and stimulant drugs [J].
Berke, J. D. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2009, 30 (05) :848-859
[8]   Oscillatory entrainment of striatal neurons in freely moving rats [J].
Berke, JD ;
Okatan, M ;
Skurski, J ;
Eichenbaum, HB .
NEURON, 2004, 43 (06) :883-896
[9]   Functional properties of striatal fast-spiking interneurons [J].
Berke, Joshua D. .
FRONTIERS IN SYSTEMS NEUROSCIENCE, 2011, 5
[10]   High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels [J].
Berndt, Andre ;
Schoenenberger, Philipp ;
Mattis, Joanna ;
Tye, Kay M. ;
Deisseroth, Karl ;
Hegemann, Peter ;
Oertner, Thomas G. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (18) :7595-7600
123456789