Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages

被引：25

作者：

Deng, Sa ^{[1
]}

Zhang, Bao Jing ^{[1
]}

Wang, Chang Yuan ^{[1
]}

Tian, Yan ^{[1
]}

Yao, Ji Hong ^{[1
]}

An, Lei ^{[1
]}

Huang, Shan Shan ^{[1
]}

Peng, Jin Yong ^{[1
]}

Liu, Ke Xin ^{[1
]}

Ma, Xiao Chi ^{[1
]}

机构：

[1] Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116044, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Deoxyandrographolide; Biotransformation; NO inhibition; Ent-labdane; ANDROGRAPHOLIDE; ANTICANCER; ALPHA;

D O I：

10.1016/j.bmcl.2011.12.122

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of analogues of deoxyandrographolide (1) transformed by Cunninghamella blakesleana AS 3.2004 were isolated and identified by spectral methods including 2D NMR. Among them, 3-oxo-17,19-dihydroxy-7,13-ent-labdadien-15,16-olide (9), 3-oxo-19-hydroxy-1,13-ent-labdadien-15,16-olide (16), 3-oxo-1 beta-hydroxy-14-deoxy-andrographolide (17) and 3-oxo-2 beta-hydroxy-14-deoxyandrographolide (18) are new compounds. And their structure-activity relationships (SAR) of inhibitory activity on LPS-induced NO production in RAW 264.7 macrophage cells were also discussed. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1615 / 1618

页数：4

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