Suppression of progenitor differentiation requires the long noncoding RNA ANCR

被引：369
|
作者：
Kretz, Markus [1 ,2 ]
Webster, Dan E. [2 ]
Flockhart, Ross J. [2 ]
Lee, Carolyn S. [2 ]
Zehnder, Ashley [2 ]
Lopez-Pajares, Vanessa [2 ]
Qu, Kun [2 ]
Zheng, Grace X. Y. [2 ]
Chow, Jennifer [2 ]
Kim, Grace E. [2 ]
Rinn, John L. [3 ]
Chang, Howard Y. [2 ,4 ]
Siprashvili, Zurab [2 ]
Khavari, Paul A. [1 ,2 ]
机构：
[1] Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA 94304 USA
[2] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA
[3] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
[4] Howard Hughes Med Inst, Stanford, CA 94305 USA
来源：
GENES & DEVELOPMENT | 2012年 / 26卷 / 04期
关键词：
lncRNA; RNA-Seq; epidermis; skin; differentiation; noncoding RNA; gene regulation; X-CHROMOSOME INACTIVATION; TERMINAL DIFFERENTIATION; GENE-EXPRESSION; GENOME; CHROMATIN; SEQ; REVEALS; IDENTIFICATION; PROLIFERATION; TRANSCRIPTS;
D O I：
10.1101/gad.182121.111
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Long noncoding RNAs (lncRNAs) regulate diverse processes, yet a potential role for lncRNAs in maintaining the undifferentiated state in somatic tissue progenitor cells remains uncharacterized. We used transcriptome sequencing and tiling arrays to compare lncRNA expression in epidermal progenitor populations versus differentiating cells. We identified ANCR (anti-differentiation ncRNA) as an 855-base-pair lncRNA down-regulated during differentiation. Depleting ANCR in progenitor-containing populations, without any other stimuli, led to rapid differentiation gene induction. In epidermis, ANCR loss abolished the normal exclusion of differentiation from the progenitor-containing compartment. The ANCR lncRNA is thus required to enforce the undifferentiated cell state within epidermis.
引用
收藏
页码：338 / 343
页数：6
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