Lupus nephritis: current update

被引：122

作者：

Saxena, Ramesh ^{[1
]}

Mahajan, Tina ^{[1
]}

Mohan, Chandra ^{[1
]}

机构：

[1] UT SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2011年 / 13卷 / 05期

关键词：

MONOCYTE CHEMOATTRACTANT PROTEIN-1; MIGRATION INHIBITORY FACTOR; PLASMACYTOID DENDRITIC CELLS; INTRINSIC RENAL-CELLS; ANTI-CD4; MONOCLONAL-ANTIBODY; CYTOKINE GENE-EXPRESSION; TH1; IMMUNE-RESPONSE; GROWTH-FACTOR-BETA; T-CELLS; MYCOPHENOLATE-MOFETIL;

D O I：

10.1186/ar3378

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. The general consensus is that 60% of lupus patients will develop clinically relevant nephritis at some time in the course of their illness. Prompt recognition and treatment of renal disease is important, as early response to therapy is correlated with better outcome. The present review summarizes our current understanding of the pathogenic mechanisms underlying lupus nephritis and how the disease is currently diagnosed and treated.

引用

页数：12

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