Highly Efficient One-Step Synthesis of N-Trimethylsiloxy Alkyl Imidothioates

被引：9
作者：
Kucinski, Krzysztof [1 ]
Hreczycho, Grzegorz [1 ]
机构：
[1] Adam Mickiewicz Univ, Fac Chem, Ul Umultowska 89b, PL-61614 Poznan, Poland
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 26期
关键词：
Synthetic methods; Multicomponent reactions; Nitro compounds; Oximes; Sulfur; OXIME ETHERS; SCANDIUM(III) TRIFLATE; BISMUTH(III) TRIFLATE; CYCLIC NITRONES; ARYL HALIDES; NITROALKANES; SILYLATION; ALCOHOLS; THIOLS; HEXAMETHYLDISILAZANE;
D O I：
10.1002/ejoc.201600768
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A hitherto unknown synthetic pathway for the synthesis of N-trimethylsiloxy alkyl imidothioates has been presented. The catalyst-free route uses a range of aromatic, aliphatic, and heterocyclic thiols in the presence of nitroalkanes and hexamethyldisilazane (HMDS). This unusual method expands upon the knowledge of nitro compounds and demonstrates their importance not only as solvents but also as valuable organic reagents. This reaction proceeds under mild conditions and is characterized by excellent yields and a facile workup.
引用
收藏
页码：4577 / 4585
页数：9
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