Highly Efficient One-Step Synthesis of N-Trimethylsiloxy Alkyl Imidothioates

A hitherto unknown synthetic pathway for the synthesis of N-trimethylsiloxy alkyl imidothioates has been presented. The catalyst-free route uses a range of aromatic, aliphatic, and heterocyclic thiols in the presence of nitroalkanes and hexamethyldisilazane (HMDS). This unusual method expands upon the knowledge of nitro compounds and demonstrates their importance not only as solvents but also as valuable organic reagents. This reaction proceeds under mild conditions and is characterized by excellent yields and a facile workup.