High-dose Radiation Induced Heart Damage in a Rat Model

被引：3
作者：
Kiscsatari, Laura [1 ]
Sarkozy, Marta [4 ]
Kovari, Bence [2 ]
Varga, Zoltan [1 ]
Gomori, Kamilla [4 ]
Morvay, Nikolett [3 ]
Lepran, Istvan [3 ]
Hegyesi, Hargita [5 ]
Fabian, Gabriella [1 ]
Cserni, Balint [6 ]
Cserni, Gabor [2 ,7 ]
Csont, Tamas [4 ]
Kahan, Zsuzsanna [1 ]
机构：
[1] Univ Szeged, Dept Oncotherapy, Szeged, Hungary
[2] Univ Szeged, Dept Pathol, Szeged, Hungary
[3] Univ Szeged, Dept Pharmacol & Pharmacotherapy, Szeged, Hungary
[4] Univ Szeged, Dept Biochem, Metabol Dis & Cell Signaling Grp, Szeged, Hungary
[5] Semmelweis Univ, Coll Hlth Care, Dept Morphol & Physiol, Budapest, Hungary
[6] Univ Szeged, Fac Sci & Informat, Szeged, Hungary
[7] Bacs Kiskun Cty Teaching Hosp, Dept Pathol, Kecskemet, Hungary
来源：
IN VIVO | 2016年 / 30卷 / 05期
关键词：
Heart function; inflammatory cytokines; radiation heart damage; radiogenic fibrosis; rat model; DIFFERENTIATION FACTOR-15 GDF-15; BREAST-CANCER PATIENTS; TGF-BETA; DISEASE; IRRADIATION; FIBROSIS; RADIOTHERAPY; MYOCARDIUM; STRATEGIES; PROTEIN;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: Radiation-induced heart disease (RIHD) is a concern during radiotherapy. For its comprehensive study, an in vivo selective heart irradiation model was developed. Materials and Methods: Sprague-Dawley rats were irradiated with 50 Gy and functional imaging, biochemical (circulating growth differentiation factor-15 (GDF-15), transforming growth factor-beta (TGFbeta) and morphological (picrosirius red staining of the heart) objectives were tested. Results: Signs and symptoms of RIHD occurred >12 weeks after irradiation with tachypnea, systolic and diastolic dysfunction, cardiac hypertrophy and body development retardation. Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation. At autopsy, extensive pleural fluid was found in the irradiated animals. Interstitial fibrosis could be reliably detected and quantified in irradiated hearts after a follow-up time of 19 weeks. Conclusion: The studied parameters could be used in future experiments for testing protective agents for prevention of radiation heart injury.
引用
收藏
页码：623 / 631
页数：9
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