Hematopoietic stem cell transplantation in autoimmune diseases

被引：0

作者：

Albarracin, Flavio ^{[1
]}

Lopez Meier, Maria Jose ^{[1
]}

Naswetter, Gustavo ^{[1
]}

Longoni, Hector ^{[1
]}

机构：

[1] Univ Buenos Aires, Hosp Clin Jose de San Martin, Unidad Trasplante Medula Osea, Div Reumatol,Fac Med, RA-1053 Buenos Aires, DF, Argentina

来源：

MEDICINA-BUENOS AIRES | 2008年 / 68卷 / 02期

关键词：

hematopoietic stem cell transplantaion; autoimmune diseases; therapy;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transplantation of hematopoietic stem cells, which are capable of self renewal and reconstitution of all types of blood cells, can be a treatment for numerous potential lethal diseases, including leukemias and lymphomas. It may now be applicable for the treatment of severe autoimmune diseases, such as therapy-resistant multiple sclerosis, lupus and systemic sclerosis. Studies in animal models show that the transfer of hematopoietic stem cells can reverse autoimmunity. The outcome of ongoing clinical trials, as well as of studies in patients and animal models, will help to determine the role that stem-cell transplantation can play in the treatment of autoimmune diseases.

引用

页码：153 / 163

页数：11

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