Microglial cell origin and phenotypes in health and disease

被引：838

作者：

Saijo, Kaoru ^{[1
]}

Glass, Christopher K. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 11期

关键词：

TOLL-LIKE RECEPTORS; CENTRAL-NERVOUS-SYSTEM; PLURIPOTENT STEM-CELLS; INNATE IMMUNE-SYSTEM; ADULT-MOUSE BRAIN; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; AMYLOID-BETA; MACROPHAGE ACTIVATION; FRACTALKINE RECEPTOR;

D O I：

10.1038/nri3086

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Microglia - resident myeloid-lineage cells in the brain and the spinal cord parenchyma - function in the maintenance of normal tissue homeostasis. Microglia also act as sentinels of infection and injury, and participate in both innate and adaptive immune responses in the central nervous system. Microglia can become activated and/or dysregulated in the context of neurodegenerative disease and cancer, and thereby contribute to disease severity. Here, we discuss recent studies that provide new insights into the origin and phenotypes of microglia in health and disease.

引用

页码：775 / 787

页数：13

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