Pharmacogenomics - it's not just pharmacogenetics

被引：51
作者：
Bailey, DS [1 ]
Bondar, A [1 ]
Furness, LM [1 ]
机构：
[1] Incyte Europe Ltd, Pharmacogen Dib, Cambridge CB2 1FF, England
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 1998年 / 9卷 / 06期
关键词：
D O I：
10.1016/S0958-1669(98)80136-5
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
New technologies in both combinatorial chemistry and combinatorial biology promise to unlock new opportunities for drug discovery and lead optimisation. Using such genome-based technologies to measure the dynamic properties of pharmacological systems, pharmacogenomics can now provide an objective measure of a drug's biological efficacy, including its potential adverse effects.
引用
收藏
页码：595 / 601
页数：7
相关论文
共 60 条
[1]   Measurement of tacrolimus (FK506) and its metabolites: A review of assay development and application in therapeutic drug monitoring and pharmacokinetic studies [J].
Alak, AM .
THERAPEUTIC DRUG MONITORING, 1997, 19 (03) :338-351
[2]   Fenofibrate differently alters expression of genes encoding ATP-binding transporter proteins of the peroxisomal membrane [J].
Albet, S ;
Causeret, C ;
Bentejac, M ;
Mandel, JL ;
Aubourg, P ;
Maurice, B .
FEBS LETTERS, 1997, 405 (03) :394-397
[3]  
[Anonymous], Cytochrome P450 Drug Interaction page
[4]  
[Anonymous], SGD SACCHAROMYCES GE
[5]   Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα) [J].
Aoyama, T ;
Peters, JM ;
Iritani, N ;
Nakajima, T ;
Furihata, K ;
Hashimoto, T ;
Gonzalez, FJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) :5678-5684
[6]  
Ashby M., 1996, U.S. Patent, Patent No. [5,569,588, 5569588]
[7]  
BAILEY DS, 1997, GENETICS COMMON DIS, P241
[8]   Phenytoin-induced teratogenesis: A molecular basis for the observed developmental delay during neurulation [J].
Bennett, GD ;
Lau, F ;
Calvin, JA ;
Finnell, RH .
EPILEPSIA, 1997, 38 (04) :415-423
[9]   HEPATIC PEROXISOME PROLIFERATION IN RODENTS AND ITS SIGNIFICANCE FOR HUMANS [J].
BENTLEY, P ;
CALDER, I ;
ELCOMBE, C ;
GRASSO, P ;
STRINGER, D ;
WIEGAND, HJ .
FOOD AND CHEMICAL TOXICOLOGY, 1993, 31 (11) :857-907
[10]   A complex program of striatal gene expression induced by dopaminergic stimulation [J].
Berke, JD ;
Paletzki, RF ;
Aronson, GJ ;
Hyman, SE ;
Gerfen, CR .
JOURNAL OF NEUROSCIENCE, 1998, 18 (14) :5301-5310
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