Single-center analysis of infectious complications in older adults during the first year after kidney transplantation

被引:11
作者
Hemmersbach-Miller, Marion [1 ]
Alexander, Barbara D. [1 ]
Sudan, Debra L. [2 ]
Pieper, Carl [3 ]
Schmader, Kenneth E. [4 ,5 ]
机构
[1] Duke Univ, Med Ctr, Div Infect Dis, Box 102359, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Div Abdominal Transplant Surg, Durham, NC USA
[3] Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA
[4] Duke Univ, Med Ctr, Div Geriatr, Durham, NC USA
[5] Durham VA, GRECC, Durham, NC USA
基金
美国国家卫生研究院;
关键词
Kidney transplantation; Infection; Aged; Epidemiology; URINARY-TRACT-INFECTIONS; RENAL-TRANSPLANTATION; RISK-FACTORS; RECIPIENTS; MORTALITY; CYTOMEGALOVIRUS; EPIDEMIOLOGY; DEATH; AGE;
D O I
10.1007/s10096-018-3405-5
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Infections are among the top three causes of death of older adults in the first year after kidney transplantation (KT). Our aim was to describe infectious complications among KT recipients aged >= 65 during the first 12 months post-transplant. Single-center retrospective cohort study. Ninety-one KTs had been performed in patients >= 65 years of age between 2011 and 2015. 92.3% of the patients developed at least one infection. Infectious episodes increased the risk of future infection by 10% (p = 0.0018) with each infection portending a greater risk. At a patient level, viral (71.4%) and bacterial (70.2%) infections predominated. Urinary tract infections were the most frequent complication (30.3%), followed by cytomegalovirus infections (22.7%). Infections were the main reason for readmission. 7.7% of the patients developed rejection; and overall 3.3% lost their graft. Mortality at 1 year was 9.9%. Older KT recipients have a high incidence of infectious complications the first year after KT. Infections were the number one reason for readmission, and an infection episode predicted future infections for the individual patient. Despite these complications, the majority of older KT recipients were alive with a functioning graft at 1 year.
引用
收藏
页码:141 / 148
页数:8
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