Tumor markers as prognostic factors in treated non-small cell lung cancer

被引：0
|
作者：
Trapé, J
Buxo, J
De Olaguer, JP
Vidal, C
机构：
[1] Hosp San Juan Dios, Serv Anal Clin, Althaia Xarxa Assistencial de Manresa, Barcelona 08243, Spain
[2] Hosp San Juan Dios, Seccio Oncol, Althaia Xarxa Assistencial de Manresa, Barcelona 08243, Spain
[3] Hosp San Juan Dios, Serv Epidemiol, Althaia Xarxa Assistencial de Manresa, Barcelona 08243, Spain
来源：
ANTICANCER RESEARCH | 2003年 / 23卷 / 5B期
关键词：
CYFRA; 21-1; CEA; CA; 125; lung cancer; treatment with chemotherapy; prognostic factor;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The usefulness of tumor markers in non-small cell lung carcinoma (NSCLC) is not well defined. The aim of this study was to determine the predictive value for response to treatment and prognosis of pretreatment concentrations of tumor markers. The pretreatment levels of CEA, CA125 and CYFRA21-1 were determined by electrochemoluminiscence in 48 patients with advanced stage (IIIA-IV) NSCLC treated with platin-based chemotherapy. The sensitivity for CYFRA21-1, CA125 and CEA was 66.7%, 45.8% and 47.3%, respectively. The predictive factors for non-response to treatment were CA125>35 KU/L (OR=5.36; p=0.017) and presence of metastasis (OR=6.92, p=0.007). The prognostic factors for survival were Performance Status>1 (HR=4.22; p=0.0002), presence of metastasis (HR = 3.1; p = 0.0028) and CA125>35 KU/L (HR=2.33,p=0.02). In conclusion, CA125 is a predictive factor for response to treatment and a prognostic factor for survival in patients with NSCLC treated with chemotherapy.
引用
收藏
页码：4277 / 4281
页数：5
相关论文
共 50 条
  • [1] Prognostic impact of cytological fluid tumor markers in non-small cell lung cancer
    Cho, Arthur
    Hur, Jin
    Hong, Yoo Jin
    Lee, Hye-Jeong
    Kim, Young Jin
    Hong, Sae Rom
    Suh, Young Joo
    Im, Dong Jin
    Kim, Yun Jung
    Lee, Jae Seok
    Shim, Hyo Sup
    Choi, Byoung Wook
    TUMOR BIOLOGY, 2016, 37 (03) : 3205 - 3213
  • [2] Prognostic significance of telomerase activity and some tumor markers in non-small cell lung cancer
    Hashim, Maha
    Sayed, Magda
    Samy, Nervana
    Elshazly, Salah
    MEDICAL ONCOLOGY, 2011, 28 (01) : 322 - 330
  • [3] Prognostic significance of telomerase activity and some tumor markers in non-small cell lung cancer
    Maha Hashim
    Magda Sayed
    Nervana Samy
    Salah Elshazly
    Medical Oncology, 2011, 28 : 322 - 330
  • [4] Prognostic molecular markers in non-small cell lung cancer
    Niklinski, J
    Niklinska, W
    Laudanski, J
    Chyczewska, E
    Chyczewski, L
    LUNG CANCER, 2001, 34 : S53 - S58
  • [5] Editorial: Prognostic factors in non-small cell lung cancer
    Rahouma, Mohamed
    Baudo, Massimo
    Zhang, Jun
    Mutti, Luciano
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [6] Prognostic Factors and Markers in Non-Small Cell Lung Cancer: Recent Progress and Future Challenges
    Meira, Debora Dummer
    de Castro e Caetano, Maria Clara
    Casotti, Matheus Correia
    Zetum, Alexia Stefani Siqueira
    Goncalves, Andre Felipe Monteiro
    Moreira, Andre Rodrigues
    de Oliveira, Augusto Henrique
    Pesente, Fellipe
    Santana, Gabriel Mendonca
    de Almeida Duque, Daniel
    Pereira, Gierleson Santos Cangussu
    de Souza Cupertino de Castro, Giulia
    Pavan, Isabele Pagani
    Chagas, Joao Pedro Sarcinelli
    Bourguignon, Jose Henrique Borges
    de Oliveira, Juliana Ribeiro
    Barbosa, Karen Ruth Michio
    Altoe, Lorena Souza Castro
    Louro, Luana Santos
    Merigueti, Luiza Poppe
    Alves, Lyvia Neves Rebello
    Machado, Marlon Ramos Rosado
    Roque, Maria Luisa Rodrigues Oliveira
    Prates, Pedro Santana
    de Paula Segaua, Sayuri Honorio
    dos Santos Uchiya, Taissa
    Louro, Thomas Erik Santos
    Daleprane, Vinicius Eduardo
    Guaitolini, Yasmin Moreto
    Vicente, Creuza Rachel
    dos Reis Trabach, Raquel Silva
    de Araujo, Bruno Cancian
    de Vargas Wolfgramm dos Santos, Eldamaria
    de Paula, Flavia
    Lopes, Tiago Jose S.
    de Carvalho, Elizeu Fagundes
    Louro, Iuri Drumond
    GENES, 2023, 14 (10)
  • [7] Prognostic factors in non-small cell lung cancer surgery
    Birim, Ö
    Kappetein, AP
    van Klaveren, R
    Bogers, AMC
    EJSO, 2006, 32 (01): : 12 - 23
  • [8] Prognostic factors for gefitinib-treated postoperative recurrence in non-small cell lung cancer
    Okami, Jiro
    Taniguchi, Kazuya
    Higashiyama, Masahiko
    Maeda, Jun
    Oda, Kazuyuki
    Orita, Naoki
    Koizumi, Kyoko
    Kodama, Ken
    Kato, Kikuya
    ONCOLOGY, 2007, 72 (3-4) : 234 - 242
  • [9] Prognostic Factors in Elderly Patients with Advanced Non-Small Cell Lung Cancer Treated with Chemotherapy
    Li, Jian
    Chen, Ping
    Dai, Chun-Hua
    Li, Xiao-Qin
    Bao, Quan-Lei
    ONCOLOGY, 2009, 76 (05) : 355 - 362
  • [10] A retrospective analysis of serum tumor markers found in non-small cell lung cancer
    Hu, Qin
    Xiao, Ping
    Li, Junjie
    Yu, Pijun
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2016, 12 (01) : 117 - 120
12345