New Insight into the Mechanisms of Ginkgo biloba Extract in Vascular Aging Prevention

被引：18

作者：

Li, Xiaoxue ^{[1
]}

Lu, Liuyi ^{[2
]}

Chen, Jie ^{[3
]}

Zhang, Chao ^{[2
]}

Chen, Hong ^{[4
,5
]}

Huang, Hui ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Cardiol, Shenzhen 518033, Peoples R China

[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Peoples R China

[3] Sun Yat Sen Univ, Dept Radiat Oncol, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China

[4] Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA

[5] Harvard Med Sch, Boston Childrens Hosp, Dept Surg, Boston, MA 02115 USA

来源：

CURRENT VASCULAR PHARMACOLOGY | 2020年 / 18卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Ginkgo biloba extract (GBE); aging; vascular dysfunction; oxidative stress; inflammation; longevity pathways; SMOOTH-MUSCLE-CELL; EXTENDS LIFE-SPAN; NF-KAPPA-B; MITOCHONDRIAL OXIDATIVE STRESS; ADHESION MOLECULE EXPRESSION; OXYGEN SPECIES GENERATION; ALL-CAUSE MORTALITY; AGE-RELATED-CHANGES; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION;

D O I：

10.2174/1570161117666190621150725

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Aging-associated vascular dysfunction promotes cardiovascular diseases. Recently, Ginkgo biloba extract (GBE) has attracted considerable attention in the prevention of aged vasculature. Methods: This review discusses the pathophysiological alterations in aged vasculature and the underlying mechanisms of GBE in vascular aging suppression. Results: Both arterial stiffening and endothelial dysfunction are critical aging-related vascular phenotypes that result in the progression of cardiovascular diseases in the general population. Consistent oxidative stress and inflammatory reaction lead to vascular dysfunction. GBE ameliorates aging-related vascular dysfunction, due to its antioxidant and anti-inflammatory properties. The main effects of GBE in aged vasculature might be associated with the longevity signaling pathways. GBE also attenuates the progression of vascular aging in diabetes mellitus via regulation of glucose and lipid metabolism. Conclusion: GBE plays an important role in the prevention of vascular aging process. It is a promising therapeutic approach to ameliorate aging-related vascular dysfunction and cardiovascular diseases.

引用

页码：334 / 345

页数：12

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