Monitoring of radiation-induced germline mutation in humans

被引：0
作者：
Dubrova, YE [1 ]
机构：
[1] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England
来源：
SWISS MEDICAL WEEKLY | 2003年 / 133卷 / 35-36期
关键词：
germline mutation; minisatellite loci; ionising radiation; chernobyl; semipalatinsk;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Estimating the genetic hazards of radiation and other mutagens in humans depends on extrapolation from experimental systems. Recent data have shown that minisatellite loci provide a useful and sensitive experimental approach for monitoring radiation-induced mutation in humans. This review describes the progress made in validating this approach and presents the results of recent publications on the analysis of minisatellite mutation rates in the irradiated families.
引用
收藏
页码：474 / 478
页数：5
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